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Literature DB >> 3706491

Immunohistochemical analysis of monoclonal antibodies to renal antigens. Application in the diagnosis of renal cell carcinoma.

E Oosterwijk, D J Ruiter, J C Wakka, J W Huiskens-van der Meij, U Jonas, G J Fleuren, J Zwartendijk, P Hoedemaeker, S O Warnaar.

Abstract

Four mouse monoclonal antibodies reacting with renal proximal epithelium were characterized on normal adult tissues, fetal kidneys, and various malignancies. These four antibodies were found to react with renal cell carcinomas (RCCs) but not with a variety of other tumors. Three antibodies react only with some primary RCCs and not with metastatic RCCs. The fourth antibody, RC 38, reacts with 46 of 47 primary RCCs tested and with 8 of 13 RCC metastases. No reaction was seen with 179 tumors of various origin, which indicates that this antibody is very useful in diagnosing RCC.

Entities: Disease Species

Mesh：

Substances：
Antibodies, Monoclonal

Year: 1986 PMID： 3706491 PMCID： PMC1888313

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

19 in total

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Journal: Cancer Res Date: 1983-11 Impact factor: 12.701

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Authors: B S Wilson; K Imai; P G Natali; S Ferrone
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23 in total

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