[Chemistry and pharmacology of prednicarbate (Hoe 777), a halogen-free topical anti-inflammatory active derivative of prednisolone-17-ethyl carbonic acid ester].

Prednicarbate (Hoe 777) is a corticoid without halogenic groups (see formula Fig. 1), showing a remarkably favorable split between topical and systemic anti-inflammatory or rather corticoid effects, which could be proved by means of various animal experiments after dermal and systemic application. The topical efficacy resembles that of current corticoid preparations containing fluorine, but its systemic influence is definitely less.