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Literature DB >> 3704650

Non-Watson-Crick G.C and A.T base pairs in a DNA-antibiotic complex.

G J Quigley, G Ughetto, G A van der Marel, J H van Boom, A H Wang, A Rich.

Abstract

The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A.T and two G.C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G.C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.

Entities: Chemical

Mesh：

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Year: 1986 PMID： 3704650 DOI： 10.1126/science.3704650

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

35 in total

1. Facilitating structural transitions in DNA.

Authors: M Waring
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

2. Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.

Authors: Shan-Ho Chou; Ko-Hsin Chin; Fu-Ming Chen
Journal: Proc Natl Acad Sci U S A Date: 2002-05-14 Impact factor: 11.205

3. Computer-aided molecular modeling and design of DNA-inserting molecules.

Authors: F J van der Klein-de Gunst; J H van Boom; R M Liskamp
Journal: J Comput Aided Mol Des Date: 1992-02 Impact factor: 3.686

4. DNA recognition by quinoxaline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of triostin A and TANDEM.

Authors: C Bailly; M J Waring
Journal: Biochem J Date: 1998-02-15 Impact factor: 3.857

Non-Watson-Crick G.C and A.T base pairs in a DNA-antibiotic complex.

1. Facilitating structural transitions in DNA.

2. Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.

3. Computer-aided molecular modeling and design of DNA-inserting molecules.

4. DNA recognition by quinoxaline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of triostin A and TANDEM.

5. Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA.

Review 6. DNA structure and perturbation by drug binding.

7. Robust IR-based detection of stable and fractionally populated G-C⁺ and A-T Hoogsteen base pairs in duplex DNA.

Review 8. New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.

9. Unstable Hoogsteen base pairs adjacent to echinomycin binding sites within a DNA duplex.

10. Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage.