Literature DB >> 3703106

Peroxisomal oxidation of lignoceric acid in rat brain.

R P Singh, I Singh.   

Abstract

The oxidation of [1-14C]lignoceric acid was studied in different subcellular fractions of rat brain. The highest specific activity for oxidation of [1-14C]lignoceric acid to acetate was observed in the light mitochondrial fraction. The oxidation of [1-14C]lignoceric acid had an absolute requirement for CoASH and ATP. It was stimulated by NAD and FAD by 400 and 280 percent, respectively, whereas addition of carnitine and KCN had no effect. These properties suggest that in brain [1-14C]lignoceric acid is oxidized in peroxisomes.

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Year:  1986        PMID： 3703106     DOI： 10.1007/bf00967975

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  19 in total

1.  Alpha hydroxylation of lignoceric acid in brain. Subcellular localization of alpha hydroxylation and the requirement for heat-stable and heat-labile factors and sphingosine.

Authors:  I Singh; Y Kishimoto
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

2.  Mitochondrial and peroxisomal beta-oxidation of fatty acids in rat liver.

Authors:  G P Mannaerts; L J Debeer
Journal:  Ann N Y Acad Sci       Date:  1982       Impact factor: 5.691

Review 3.  Metabolic pathways in peroxisomes and glyoxysomes.

Authors:  N E Tolbert
Journal:  Annu Rev Biochem       Date:  1981       Impact factor: 23.643

4.  Cerebro-hepato-renal (Zellweger) syndrome and neonatal adrenoleukodystrophy: similarities in phenotype and accumulation of very long chain fatty acids.

Authors:  F R Brown; A J McAdams; J W Cummins; R Konkol; I Singh; A B Moser; H W Moser
Journal:  Johns Hopkins Med J       Date:  1982-12

5.  The cerebrohepatorenal (Zellweger) syndrome. Increased levels and impaired degradation of very-long-chain fatty acids and their use in prenatal diagnosis.

Authors:  A E Moser; I Singh; F R Brown; G I Solish; R I Kelley; P J Benke; H W Moser
Journal:  N Engl J Med       Date:  1984-05-03       Impact factor: 91.245

6.  Adrenoleukodystrophy: impaired oxidation of very long chain fatty acids in white blood cells, cultured skin fibroblasts, and amniocytes.

Authors:  I Singh; A E Moser; H W Moser; Y Kishimoto
Journal:  Pediatr Res       Date:  1984-03       Impact factor: 3.756

7.  Neonatal adrenoleukodystrophy: clinical, pathologic, and biochemical delineation of a syndrome affecting both males and females.

Authors:  R Jaffe; P Crumrine; Y Hashida; H W Moser
Journal:  Am J Pathol       Date:  1982-07       Impact factor: 4.307

8.  Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy.

Authors:  I Singh; A E Moser; S Goldfischer; H W Moser
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

9.  Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy.

Authors:  H W Moser; A E Moser; I Singh; B P O'Neill
Journal:  Ann Neurol       Date:  1984-12       Impact factor: 10.422

10.  Glutamate formed from lignoceric acid by rat brain preparation in the presence of pyridine nucleotide and cytosolic factors: a brain-specific oxidation of very long chain fatty acids.

Authors:  M Uda; I Singh; Y Kishimoto
Journal:  Biochemistry       Date:  1981-03-03       Impact factor: 3.162
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  2 in total

Review 1.  Biochemistry of peroxisomes in health and disease.

Authors:  I Singh
Journal:  Mol Cell Biochem       Date:  1997-02       Impact factor: 3.396

2.  Fatty acid metabolism in renal ischemia.

Authors:  E Ruidera; C E Irazu; P R Rajagopalan; J K Orak; C T Fitts; I Singh
Journal:  Lipids       Date:  1988-09       Impact factor: 1.880
  2 in total

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