| Literature DB >> 3701302 |
P C Grauballe, A Hornsleth, K Hjelt, P A Krasilnikoff.
Abstract
IgG subclass-specific antibody responses to a human subgroup 2 rotavirus were studied in 26 children by ELISA by use of monoclonal antibodies specific to the four human IgG subclasses. One hundred twenty-nine serum samples were obtained before, during, and after an episode of rotavirus-induced diarrhoea in these patients. When these sera were investigated, an increase in IgG1 and IgG3 subclass-specific antibodies was detected in all 26 patients. IgG3 antibodies reached a peak concentration 1 week after rotavirus was detected in faecal samples and then progressively declined over the following months, whereas the peak concentration of IgG1 subclass antibodies was found 2 months later and seemed to persist thereafter. IgG2 rotavirus-specific subclass antibodies were never found and IgG4 subclass antibodies were detected only in sera from seven of the 26 patients.Entities:
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Year: 1986 PMID: 3701302 DOI: 10.1002/jmv.1890180309
Source DB: PubMed Journal: J Med Virol ISSN: 0146-6615 Impact factor: 2.327