Literature DB >> 3700464

Induction of Sertoli cell tumors in the rat ovary by N-alkyl-N-nitrosoureas.

A Maekawa, H Onodera, H Tanigawa, J Kanno, K Furuta, Y Hayashi.   

Abstract

Relatively high incidences of Sertoli cell tumors of the ovary were induced in Donryu rats given a 400 ppm N-ethyl-N-nitrosourea solution as drinking water for 4 weeks or a single dose of 200 mg/kg N-propyl-N-nitrosourea by stomach tube. Typical Sertoli cell tumors were composed of solid areas showing tubular formation. Tubules were lined by tall, columnar cells having abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented round nuclei. In some cases, Sertoli cell tumors were found to be mixed with granulosa cell tumors.

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Year:  1986        PMID： 3700464     DOI： 10.1007/bf00400760

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  7 in total

1.  Experimental ovarian tumors in rats.

Authors:  G R BISKIND; M S BISKIND
Journal:  Am J Clin Pathol       Date:  1949-06       Impact factor: 2.493

2.  Reduction of N-nitroso-N-ethylurea-induced neurogenic tumors by X-radiation: a life-span study in rats.

Authors:  J F Knowles
Journal:  J Natl Cancer Inst       Date:  1984-01       Impact factor: 13.506

3.  Carcinogenicity of low doses of N-ethyl-N-nitrosourea in F344 rats; a dose-response study.

Authors:  A Maekawa; T Ogiu; C Matsuoka; H Onodera; K Furuta; Y Kurokawa; M Takahashi; T Kokubo; H Tanigawa; Y Hayashi
Journal:  Gan       Date:  1984-02

4.  Rapid and selective induction of erythroleukemia in female Donryu rats by continuous oral administration of 1-ethyl-1-nitrosourea.

Authors:  T Ogui; M Nakadate; S Odashima
Journal:  Cancer Res       Date:  1976-09       Impact factor: 12.701

5.  Carcinogenicity of N-nitroso compounds. Species and route differences in regard to organotropism.

Authors:  D Schmähl; M Habs
Journal:  Oncology       Date:  1980       Impact factor: 2.935

6.  Cancer of rat ovaries: Sertoli cell or granulosa-theca cell tumours?

Authors:  J F Knowles
Journal:  Br J Cancer       Date:  1983-08       Impact factor: 7.640

7.  A new model for inducing malignant ovarian tumours in rats.

Authors:  J Hilfrich
Journal:  Br J Cancer       Date:  1973-07       Impact factor: 7.640
  7 in total
  3 in total

1.  In vitro malignant transformation of in vivo ENU-induced rat ovarian Sertoli cell tumor (adenoma).

Authors:  G Stoica; M O'Leary
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

2.  High yields of granulosa cell tumors/luteomas in F344 rat ovaries after transplacental administration of N-nitrosobis(2-oxopropyl)amine.

Authors:  A Maekawa; H Onodera; Y Matsushima; T Nagaoka; A Todate; J Kanno; M Shibutani; H Ogasawara; J Yoshida; Y Hayashi
Journal:  Jpn J Cancer Res       Date:  1990-11

3.  Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Authors:  A Maekawa; H Onodera; H Tanigawa; K Furuta; J Kanno; T Ogiu; Y Hayashi
Journal:  Environ Health Perspect       Date:  1987-08       Impact factor: 9.031
  3 in total

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