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Literature DB >> 3700463

Application of a subcellular membrane-antibody binding assay for the analysis of antigen expression in human tumours.

Abstract

A micro-radioisotopic antiglobulin assay has been employed to determine the binding of monoclonal antibodies to subcellular membranes adsorbed to the wells of Terasaki Microtest Plates. A panel of 15 monoclonal antibodies was tested against 22 membrane preparations isolated from normal and malignant colo-rectal, breast and lung tissues. The assay provided an objective evaluation of antibody reactivity permitting the expression of major antigens in samples from individual surgical specimens to be defined.

Entities: Disease Species

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Year: 1986 PMID： 3700463 DOI： 10.1007/bf00400759

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

13 in total

1. Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.

Authors: J Burchell; H Durbin; J Taylor-Papadimitriou
Journal: J Immunol Date: 1983-07 Impact factor: 5.422

2. A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains.

Authors: A Brown; T Feizi; H C Gooi; M J Embleton; J K Picard; R W Baldwin
Journal: Biosci Rep Date: 1983-02 Impact factor: 3.840

3. Antigenic subsets of human breast epithelial cells distinguished by monoclonal antibodies.

Authors: P A Edwards; I M Brooks
Journal: J Histochem Cytochem Date: 1984-05 Impact factor: 2.479

4. Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.

Authors: J Taylor-Papadimitriou; J A Peterson; J Arklie; J Burchell; R L Ceriani; W F Bodmer
Journal: Int J Cancer Date: 1981-07-15 Impact factor: 7.396

5. Monoclonal antibodies recognizing epitopes carried on both glycolipids and glycoproteins of the human milk fat globule membrane.

Authors: R A McIlhinney; S Patel; M E Gore
Journal: Biochem J Date: 1985-04-01 Impact factor: 3.857

Application of a subcellular membrane-antibody binding assay for the analysis of antigen expression in human tumours.

1. Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.

2. A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains.

3. Antigenic subsets of human breast epithelial cells distinguished by monoclonal antibodies.

4. Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.

5. Monoclonal antibodies recognizing epitopes carried on both glycolipids and glycoproteins of the human milk fat globule membrane.

6. Radioimmunodetection of human colorectal cancers by an anti-tumour monoclonal antibody.

7. Multiple epitopes on a human breast-carcinoma-associated antigen.

8. Immunocytochemical staining of breast carcinoma with the monoclonal antibody NCRC 11: a new prognostic indicator.

9. Antitumour reactions of monoclonal antibody against a human osteogenic-sarcoma cell line.

10. Preparation of aminoazo dye induced rat hepatoma membrane fractions retaining tumour specific antigen.

1. Mapping of monoclonal antibody-defined epitopes associated with carcinoembryonic antigen, CEA.

2. Epitope analysis of monoclonal antibody NCRC-11 defined antigen isolated from human ovarian and breast carcinomas.