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Literature DB >> 370015

Adjuvants in the induction of suppressor cells.

Abstract

The effect of different mycobacterial adjuvants on the parameters of delayed hypersensitivity was investigated in strain 13 guinea pigs. The composition of the tubercle bacilli and the type of vehicle in which the antigen was presented determined the presence and extent of suppressor cell activity. When antigen was introduced in complete Freund adjuvant, both adherent and nonadherent cells had suppressive properties, with the suppressive effect demonstrable in vitro from 1 to 5 weeks after sensitization. Suppressor activity was indicated in vivo by a reduction of delayed footpad hypersensitivity in animals presensitized with complete Freund adjuvant.

Entities: Chemical Disease Species

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Year: 1979 PMID： 370015 PMCID： PMC414173 DOI： 10.1128/iai.23.2.360-365.1979

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

1. Impairment of immunological reactivity in guinea pigs by prior injection of adjuvant.

Authors: B D JANKOVIC
Journal: Nature Date: 1962-02-24 Impact factor: 49.962

2. The effect of cyclophosphamide on suppressor cells in guinea pigs.

Authors: R Neta; A Winkelstein; S B Salvin; H Mendelow
Journal: Cell Immunol Date: 1977-10 Impact factor: 4.868

Review 3. Immunological enhancement: a study of blocking antibodies.

Authors: J D Feldman
Journal: Adv Immunol Date: 1972 Impact factor: 3.543

4. Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients.

Authors: T Y Ha; B H Waksman
Journal: J Immunol Date: 1973-05 Impact factor: 5.422

5. Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. II. Mechanism of the phenomenon.

Authors: G G Allwood; G L Asherson
Journal: Clin Exp Immunol Date: 1971-08 Impact factor: 4.330

6. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity.

Authors: R Neta; S B Salvin
Journal: J Immunol Date: 1974-12 Impact factor: 5.422

7. T and B lymphocytes in the regulation of delayed hypersensitivity.

Authors: R Neta; S B Salvin
Journal: J Immunol Date: 1976-11 Impact factor: 5.422

8. Regulation of the antibody response to type 3 pneumococcal polysaccharide. II. Mode of action of thymic-derived suppressor cells.

Authors: P J Baker; P W Stashak; D F Amsbaugh; B Prescott
Journal: J Immunol Date: 1974-01 Impact factor: 5.422

9. Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis.

Authors: J E Swierkosz; R H Swanborg
Journal: J Immunol Date: 1975-09 Impact factor: 5.422

10. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.

Authors: G B MACKANESS
Journal: J Exp Med Date: 1964-07-01 Impact factor: 14.307

7 in total

1. Mechanisms in the in vivo release of lymphokines: relationship of high and low responsiveness to other parameters of the immune response.

Authors: R Neta; S B Salvin
Journal: Infect Immun Date: 1981-10 Impact factor: 3.441

2. Suppressor cell regulation of cell-mediated immune responses in renal infection in vitro modulation of suppressor cell activity.

Authors: T Miller; E Marshall
Journal: J Clin Invest Date: 1980-10 Impact factor: 14.808

6. Effect of route of Mycobacterium bovis BCG administration on induction of suppression of sporozoite immunity in rodent malaria.

Authors: L L Smrkovski
Journal: Infect Immun Date: 1981-01 Impact factor: 3.441

7. Induction of delayed type hypersensitivity against ultrasonicated Mycobacterium lepraemurium bacilli without simultaneous local reactivity against live bacilli or protective immunity.

Authors: M Løvik; O Closs
Journal: Clin Exp Immunol Date: 1983-08 Impact factor: 4.330