Literature DB >> 369993

Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol.

Y Rosenstein, C Lafarge-Frayssinet, G Lespinats, F Loisillier, P Lafont, C Frayssinet.   

Abstract

The inhibitory effect of crude Fusarium poae extracts, T2-toxin and diacetoxyscirpenol on synthesis of antibody to sheep red blood cells was investigated, as well as the effect of T2-toxin on skin graft rejection. Fusarium crude extracts, T2-toxin and diacetoxyscirpenol cause a significant reduction in thymus weight and inhibit responsiveness to sheep red blood cells. The effect on antibody synthesis was critically dependent on the drug doses used. The effect of an immunosuppressive dose of T2-toxin disappeared within 6 days after the end of the treatment. The administration of T2-toxin subsequent to immunization stops antibody synthesis. T2-toxin significantly prolongs the period required for skin graft rejection.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 369993      PMCID： PMC1457389     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  12 in total

1.  Prevention, by ribosome-bound nascent polyphenylalanine chains, of the functional interaction of t-2 toxin with its receptor site.

Authors:  M Cannon; K E Smith; C J Carter
Journal:  Biochem J       Date:  1976-05-15       Impact factor: 3.857

2.  [Toxic metabolites from Fusarium causing alimentary toxic aleukia (author's transl)].

Authors:  P Lafont; C Lafarge-Frayssinet; J Lafont; G Bertin
Journal:  Ann Microbiol (Paris)       Date:  1977 Aug-Sep

3.  Follicular lymphoma with deposits of amorphous hyaline material.

Authors:  A Talerman; H P Platenburg
Journal:  J Pathol       Date:  1974-01       Impact factor: 7.996

4.  Reconfirmation of the specific nature of reticulocytes bioassay system to trichothec mycotoxins of Fusarium spp.

Authors:  Y Ueno; N Shimada
Journal:  Chem Pharm Bull (Tokyo)       Date:  1974-11       Impact factor: 1.645

5.  Toxicological approaches to the metabolites of Fusaria. V. Neosolaniol, T-2 toxin and butenolide, toxic metabolites of Fusarium sporotrichioides NRRL 3510 and Fusarium poae 3287.

Authors:  Y Ueno; N Sato; K Ishii; K Sakai; M Enomoto
Journal:  Jpn J Exp Med       Date:  1972-10

6.  Toxicological approaches to the metabolites of Fusaria. 3. Acute toxicity of fusarenon-X.

Authors:  Y Ueno; I Ueno; Y Iitoi; H Tsunoda; M Enomoto
Journal:  Jpn J Exp Med       Date:  1971-12

7.  Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins.

Authors:  E Cundliffe; M Cannon; J Davies
Journal:  Proc Natl Acad Sci U S A       Date:  1974-01       Impact factor: 11.205

8.  Toxicological approaches to the toxic metabolites of Fusaria. VIII. Acute and subacute toxicities of T-2 toxin in cats.

Authors:  N Sato; Y Ueno; M Enomoto
Journal:  Jpn J Pharmacol       Date:  1975-06

9.  Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis.

Authors:  L L Liao; A P Grollman; S B Horwitz
Journal:  Biochim Biophys Acta       Date:  1976-12-01

10.  Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle.

Authors:  I C Hsu; E B Smalley; F M Strong; W E Ribelin
Journal:  Appl Microbiol       Date:  1972-11
View more
  23 in total

1.  Macrocyclic trichothecenes produced by Stachybotrys isolated from Egypt and eastern Europe.

Authors:  O M el-Maghraby; G A Bean; B B Jarvis; M B Aboul-Nasr
Journal:  Mycopathologia       Date:  1991-02       Impact factor: 2.574

2.  Mozart's illnesses and death.

Authors:  R Schoental
Journal:  J R Soc Med       Date:  1984-02       Impact factor: 5.344

3.  T-2 toxin impairment of murine response to Salmonella typhimurium: a histopathologic assessment.

Authors:  J H Tai; J J Pestka
Journal:  Mycopathologia       Date:  1990-03       Impact factor: 2.574

4.  Immunotoxicity of repeated low level exposure to T-2 toxin, a trichothecene mycotoxin, in CD-1 mice.

Authors:  M J Taylor; R V Reddy; R P Sharma
Journal:  Mycotoxin Res       Date:  1985-09       Impact factor: 3.833

5.  In vitro effects of diacetoxyscirpenol (DAS) on human and rat granulo-monocytic progenitors.

Authors:  S Lautraite; B Rio; J Guinard; D Parent-Massin
Journal:  Mycopathologia       Date:  1997       Impact factor: 2.574

6.  Use of cell cultures for predicting the biological effects of mycotoxins.

Authors:  S Robbana-Barnat; C Lafarge-Frayssinet; C Frayssinet
Journal:  Cell Biol Toxicol       Date:  1989-06       Impact factor: 6.691

7.  Embryotoxic effects of prenatal T-2 toxin exposure in mice.

Authors:  B R Blakley; D S Hancock; C G Rousseaux
Journal:  Can J Vet Res       Date:  1987-07       Impact factor: 1.310

8.  In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of murine peritoneal macrophages.

Authors:  A M Ayral; N Dubech; J Le Bars; L Escoula
Journal:  Mycopathologia       Date:  1992-11       Impact factor: 2.574

9.  Subacute toxicity of dietary T-2 toxin in mice: morphological and hematological effects.

Authors:  M A Hayes; J E Bellamy; H B Schiefer
Journal:  Can J Comp Med       Date:  1980-04

10.  Effect of T-2 toxin on the bovine immune system: humoral factors.

Authors:  D D Mann; G M Buening; B S Hook; G D Osweiler
Journal:  Infect Immun       Date:  1982-06       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.