| Literature DB >> 3699438 |
M Auguet, S Delaflotte, F Clostre, F V DeFeudis.
Abstract
The actions of four Ca2+-antagonists (verapamil, diltiazem, nifedipine and flunarizine) were tested on serotonin- (5-HT-) induced contraction of rabbit isolated aorta. Verapamil produced a dose-dependent, parallel shift to the right of the concentration-response curve for 5-HT (pA2 approximately equal to 7.13; Schild slope approximately equal to 1.01), indicative of competitive antagonism. The effects of diltiazem, nifedipine and flunarizine were much less pronounced and best characterized as non-competitive interactions. The effect of verapamil, which likely involves its antagonism of smooth muscle 5-HT2-receptors, might be useful in explaining its therapeutic actions and/or its side-effects.Entities:
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Year: 1986 PMID： 3699438 DOI： 10.1016/0306-3623(86)90129-1
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623