Literature DB >> 3698925

Hyperglycemic activity in dogs of recombinant DNA-derived 20,000 dalton variant of methionyl human growth hormone.

C J Shaar, E L Grinnan, W G Short, J G Powell, N Bryan, K G Bemis, F C Tinsley.   

Abstract

The recombinant DNA-derived 20,000-dalton variant of N-terminal methionyl human growth hormone (20K-Met-hGH) had a hyperglycemic effect in fasted dogs when injected 11 hours prior to an oral glucose tolerance test (OGTT). These results reported here suggest that 20K-Met-hGH can induce glucose intolerance in dogs similar to that produced by recombinant DNA-derived 22,000 dalton N-terminal methionyl human growth hormone (22K-Met-hGH) and the normal pituitary-source human growth hormone (22K-hGH).

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Year:  1986        PMID: 3698925     DOI: 10.1080/07435808609023651

Source DB:  PubMed          Journal:  Endocr Res        ISSN: 0743-5800            Impact factor:   1.720


  1 in total

1.  Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans.

Authors:  Jenny Tong; David D'Alessio; Juliane Ramisch; Harold W Davis; Elizabeth Stambrook; Matthias H Tschöp; Martin Bidlingmaier
Journal:  J Clin Endocrinol Metab       Date:  2012-06-28       Impact factor: 5.958

  1 in total

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