Literature DB >> 3697151

Preparation and biological activity of 5,6-dihydro-5-azapyrimidine nucleosides.

A Pískala1, B Cesneková, J Veselý.   

Abstract

The reaction of 5-azapyrimidine nucleosides Ia-IXa with zinc powder in acetic acid afforded the respective 5,6-dihydro derivatives Ib-IXb in high yields. This procedure represents a convenient and general method for preparation of the title compounds. The effects of some dihydro-5-azapyrimidine nucleosides on the growth in vitro of L1210 mouse leukemic cells were estimated.

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Year:  1987        PMID: 3697151

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN: 0261-3166


  1 in total

1.  2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential.

Authors:  Marika Matoušová; Ivan Votruba; Miroslav Otmar; Eva Tloušťová; Jana Günterová; Helena Mertlíková-Kaiserová
Journal:  Epigenetics       Date:  2011-06-01       Impact factor: 4.528

  1 in total

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