Literature DB >> 3696492

Apamin and d-tubocurarine block the afterhyperpolarization of rat supraoptic neurosecretory neurons.

C W Bourque1, D A Brown.   

Abstract

Magnocellular neurosecretory cells (MNCs) were impaled in perfused explants of rat hypothalamus. Evoked bursts of spikes were followed by an afterhyperpolarization (AHP) lasting 1-2 s. In each of 22 cells this AHP was selectively suppressed by low nanomolar concentrations of apamin (IC50 = 1.3 nM) or micromolar concentrations of d-tubocurarine (IC50 approximately 40 microM). Blockade of the AHP was accompanied by a decrease in spike accommodation and an unmasking of the late depolarizing afterpotential which induces burst firing in MNCs. Modulation of the Ca2+-dependent K+ (AHP) conductance by an endogenous apamin-like ligand could play an important role in the control of firing rate and pattern in MNCs.

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Year:  1987        PMID： 3696492     DOI： 10.1016/0304-3940(87)90127-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  41 in total

1.  An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons.

Authors:  M Stocker; M Krause; P Pedarzani
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-13       Impact factor: 11.205

2.  Electrophysiological and morphological properties of pre-autonomic neurones in the rat hypothalamic paraventricular nucleus.

Authors:  J E Stern
Journal:  J Physiol       Date:  2001-11-15       Impact factor: 5.182

3.  AHP's, HAP's and DAP's: how potassium currents regulate the excitability of rat supraoptic neurones.

Authors:  Peter Roper; Joseph Callaway; Talent Shevchenko; Ryoichi Teruyama; William Armstrong
Journal:  J Comput Neurosci       Date:  2003 Nov-Dec       Impact factor: 1.621

4.  Enhancement of calcium-dependent afterpotentials in oxytocin neurons of the rat supraoptic nucleus during lactation.

Authors:  Ryoichi Teruyama; William E Armstrong
Journal:  J Physiol       Date:  2005-05-05       Impact factor: 5.182

5.  A novel osmosensitive voltage gated cation current in rat supraoptic neurones.

Authors:  Xiao-Hong Liu; Wenbo Zhang; Thomas E Fisher
Journal:  J Physiol       Date:  2005-08-11       Impact factor: 5.182

6.  A reduction in SK channels contributes to increased activity of hypothalamic magnocellular neurons during heart failure.

Authors:  Hildebrando C Ferreira-Neto; Vinicia C Biancardi; Javier E Stern
Journal:  J Physiol       Date:  2017-08-02       Impact factor: 5.182

7.  Electrophysiological characteristics of immunochemically identified rat oxytocin and vasopressin neurones in vitro.

Authors:  W E Armstrong; B N Smith; M Tian
Journal:  J Physiol       Date:  1994-02-15       Impact factor: 5.182

8.  Calcium-activated hyperpolarizations in neurons of the mediolateral part of the lateral septum: intracellular studies from guinea pig brain slices.

Authors:  B Carette
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

9.  Central blockade of oxytocin receptors during mid-late gestation reduces amplitude of slow afterhyperpolarization in supraoptic oxytocin neurons.

Authors:  R Teruyama; D L Lipschitz; L Wang; G R Ramoz; W R Crowley; S L Bealer; W E Armstrong
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-09-23       Impact factor: 4.310

10.  Caesium blocks depolarizing after-potentials and phasic firing in rat supraoptic neurones.

Authors:  M Ghamari-Langroudi; C W Bourque
Journal:  J Physiol       Date:  1998-07-01       Impact factor: 5.182
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