Literature DB >> 369259

The antiarrhythmic action of prostacyclin (PGI2) on aconitine induced arrhythmias in rats.

H J Mest, W Förster.   

Abstract

Prostacyclin (PGI2) produces an antiarrhythmic effect on aconitine induced arrhythmias in rats. The ED50 of PGI2 was 0.7 microgram/kg and the maximum antiarrhythmic effect 54 per cent. The equi-effective doses of PGE2 and PGF2alpha were higher (ED50 of PGF2alpha = 1.2 microgram/kg, ED50 of PGE2 = 2.7 microgram/kg). However, PGF2alpha and PGE2 had a maximum antiarrhythmic effect of 80 per cent in this model.

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Year:  1978        PMID： 369259

Source DB:  PubMed          Journal:  Acta Biol Med Ger        ISSN： 0001-5318


  4 in total

1.  Prostacyclin and iloprost: equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation.

Authors:  M Pissarek; H Goos; J Nöhring; J Graff; G Buller; I Beyerdörfer; H J Mest; K F Lindenau; E G Krause
Journal:  Basic Res Cardiol       Date:  1987 Nov-Dec       Impact factor: 17.165

2.  Platelet-release reaction in myocardial infarction.

Authors:  D P Mikhailidis; P Dandona
Journal:  Br Med J       Date:  1980-03-29

3.  The effects of extracellular potassium, ouabain, and prostaglandins on intracellular potassium activity in sheep cardica Purkinje fibers.

Authors:  M Wiederholt; P Danisevskis; L L Hansen; H J Lichey; K D Platsch
Journal:  Pflugers Arch       Date:  1980-11       Impact factor: 3.657

4.  International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.

Authors:  Xavier Norel; Yukihiko Sugimoto; Gulsev Ozen; Heba Abdelazeem; Yasmine Amgoud; Amel Bouhadoun; Wesam Bassiouni; Marie Goepp; Salma Mani; Hasanga D Manikpurage; Amira Senbel; Dan Longrois; Akos Heinemann; Chengcan Yao; Lucie H Clapp
Journal:  Pharmacol Rev       Date:  2020-10       Impact factor: 25.468
  4 in total

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