Literature DB >> 3691793

Multiple effects of alpha-toxins on the nicotinic acetylcholine receptor.

R J Bradley1, M K Pagala, M T Edge.   

Abstract

Very low concentrations (5 nM) of alpha-toxin from the venom of Naja naja atra produced a characteristic fade in muscle compound action potential and tetanus induced by repetitive nerve stimulation which was identical to the effects of curare. High concentrations of alpha-toxin and all concentrations of alpha-bungarotoxin reduced the response but produced very little fade in comparison to curare. These results suggest that alpha-toxins have more than one effect at the neuromuscular junction.

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Year:  1987        PMID: 3691793     DOI: 10.1016/0014-5793(87)80469-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  2 in total

1.  Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus).

Authors:  S Nirthanan; E Charpantier; P Gopalakrishnakone; M C E Gwee; H E Khoo; L S Cheah; R M Kini; D Bertrand
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

2.  Run-down of neuromuscular transmission during repetitive nerve activity by nicotinic antagonists is not due to desensitization of the postsynaptic receptor.

Authors:  S J Hong; C C Chang
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

  2 in total

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