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Literature DB >> 3691735

Mechanical parameters determined in dispersed ventricular heart cells.

Abstract

A high-resolution laser diffraction system suitable for studying the basic mechanical properties of small contractile single cells has been developed. This method was used to establish the mechanical behavior of 95 ventricular cells isolated from adult guinea pig hearts. During contraction, the sarcomere length shortened from 1828 +/- 43 nm (mean +/- SD) to 1518 +/- 99 nm. The maximal velocities were 1.98 +/- 0.64 micron/s for shortening and 1.93 +/- 0.54 micron/s for re-lengthening. The twitch duration from 20% shortening to 80% re-lengthening was 622 +/- 120 ms.

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Calcium

Year: 1987 PMID： 3691735 DOI： 10.1007/bf01945514

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

13 in total

1. The two components in the shortening of unloaded ventricular myocytes: their voltage dependence.

Authors: G Isenberg; A Beresewicz; D Mascher; F Valenzuela
Journal: Basic Res Cardiol Date: 1985 Impact factor: 17.165

2. Cell pairs isolated from adult guinea pig and rat hearts: effects of [Ca2+]i on nexal membrane resistance.

Authors: P Maurer; R Weingart
Journal: Pflugers Arch Date: 1987-08 Impact factor: 3.657

3. A laser diffraction system with improved sensitivity for long-time measurements of sarcomere dynamics in isolated cardiac myocytes.

Authors: E Niggli
Journal: Pflugers Arch Date: 1988-04 Impact factor: 3.657

Mechanical parameters determined in dispersed ventricular heart cells.

1. The two components in the shortening of unloaded ventricular myocytes: their voltage dependence.

2. Cell pairs isolated from adult guinea pig and rat hearts: effects of [Ca2+]i on nexal membrane resistance.

3. A laser diffraction system with improved sensitivity for long-time measurements of sarcomere dynamics in isolated cardiac myocytes.

Review 4. Electrophysiology of single cardiac cells.

5. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

6. Velocity of sarcomere shortening in rat cardiac muscle: relationship to force, sarcomere length, calcium and time.

Review 7. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart.

8. The effects of insulin and anoxia on the metabolism of isolated mature rat cardiac myocytes.

9. Influence of a change in stimulation rate on action potentials, currents and contractions in rat ventricular cells.

10. Uniform sarcomere shortening behavior in isolated cardiac muscle cells.

1. Restoring forces in cardiac myocytes. Insight from relaxations induced by photolysis of caged ATP.