Literature DB >> 3691600

Methylergometrine antagonizes 5 HT in the temporal artery.

P Tfelt-Hansen1, I Jansen, L Edvinsson.   

Abstract

Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be compared in prophylactic trials in migraine.

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Year:  1987        PMID： 3691600     DOI： 10.1007/bf00610384

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

1.  METHYSERGIDE IN THE MIGRAINE SYNDROME.

Authors:  R B SHEKELLE; A M OSTFELD
Journal:  Clin Pharmacol Ther       Date:  1964 Mar-Apr       Impact factor: 6.875

2.  Selective vasoconstriction in carotid vascular bed by methysergide: possible relevance to its antimigraine effect.

Authors:  P R Saxena
Journal:  Eur J Pharmacol       Date:  1974-06       Impact factor: 4.432

Review 3.  Basic mechanisms of antimigraine drugs.

Authors:  J R Fozard
Journal:  Adv Neurol       Date:  1982

4.  Antimigraine drugs and cranial arteriovenous shunting in the cat.

Authors:  E L Spierings; P R Saxena
Journal:  Neurology       Date:  1980-07       Impact factor: 9.910

5.  Effects of methysergide, pizotifen and ergotamine in the monkey cranial circulation.

Authors:  E J Mylecharane; P J Spira; J Misbach; J W Duckworth; J W Lance
Journal:  Eur J Pharmacol       Date:  1978-03-01       Impact factor: 4.432

6.  Pharmacokinetics of methysergide and its metabolite methylergometrine in man.

Authors:  U Bredberg; G S Eyjolfsdottir; L Paalzow; P Tfelt-Hansen; V Tfelt-Hansen
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

7.  Methylergometrine, an active metabolite of methysergide.

Authors:  E Müller-Schweinitzer; C Tapparelli
Journal:  Cephalalgia       Date:  1986-03       Impact factor: 6.292

8.  Characterization of 5-hydroxytryptamine receptors in human temporal arteries: comparison between migraine suffers and nonsufferers.

Authors:  T Skärby; P Tfelt-Hansen; F Gjerris; L Edvinsson; J Olesen
Journal:  Ann Neurol       Date:  1982-09       Impact factor: 10.422
  8 in total
  2 in total

1.  Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction.

Authors:  S J MacLennan; G R Martin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-08       Impact factor: 3.000

2.  Arterial diameter during central volume depletion in humans.

Authors:  H K Iversen; P Madsen; S Matzen; N H Secher
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1995
  2 in total

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