Literature DB >> 3691443

Dose-response curves for erythrocyte protoporphyrin vs blood lead: effects of iron status.

A H Marcus1, J Schwartz.   

Abstract

An increase in erythrocyte protoporphyrin (EP) is one of the most useful indicators of adverse biological response to lead exposure. A nonlinear mathematical model relating EP to blood lead concentration (PbB) was fitted to data in a sample of 1677 U.S. children (ages 2-6 years) in the Second National Health and Nutrition Examination Survey (NHANES II). Iron status was defined by percentage transferrin saturation (PTS). The dose-response curves for EP vs PbB increased systematically with decreasing PTS, largely due to decrease of a parameter proportional to red cell lead-holding capacity with decreasing PTS.

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Year:  1987        PMID： 3691443     DOI： 10.1016/s0013-9351(87)80230-x

Source DB:  PubMed          Journal:  Environ Res        ISSN： 0013-9351            Impact factor:   6.498


  7 in total

1.  Mechanisms of lead and manganese neurotoxicity.

Authors:  April P Neal; Tomas R Guilarte
Journal:  Toxicol Res (Camb)       Date:  2013-03-01       Impact factor: 3.524

2.  Lead-induced anemia: dose-response relationships and evidence for a threshold.

Authors:  J Schwartz; P J Landrigan; E L Baker; W A Orenstein; I H von Lindern
Journal:  Am J Public Health       Date:  1990-02       Impact factor: 9.308

3.  Impact of chronic lead exposure on selected biological markers.

Authors:  Ambica P Jangid; P J John; D Yadav; Sandhya Mishra; Praveen Sharma
Journal:  Indian J Clin Biochem       Date:  2011-09-22

4.  Evaluation of Low Blood Lead Levels and Its Association with Oxidative Stress in Pregnant Anemic Women: A Comparative Prospective Study.

Authors:  Amit Kumar Mani Tiwari; Abbas Ali Mahdi; Fatima Zahra; Sudarshna Sharma; Mahendra Pal Singh Negi
Journal:  Indian J Clin Biochem       Date:  2012-03-29

5.  Inhibition of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity in fish from waters affected by lead smelters.

Authors:  Christopher J Schmitt; Colleen A Caldwell; Bill Olsen; Dave Serdar; Mike Coffey
Journal:  Environ Monit Assess       Date:  2002-07       Impact factor: 2.513

6.  The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.

Authors:  Guangqin Fan; Guihua Du; Huijun Li; Fen Lin; Ziyong Sun; Wei Yang; Chang Feng; Gaochun Zhu; Yanshu Li; Ying Chen; Huan Jiao; Fankun Zhou
Journal:  PLoS One       Date:  2014-07-02       Impact factor: 3.240

Review 7.  Influence of the common human delta-aminolevulinate dehydratase polymorphism on lead body burden.

Authors:  J G Wetmur
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
  7 in total

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