Literature DB >> 3689819

Effect of chloroquine on biliary lipid and lysosomal enzyme output in the isolated perfused rat liver at low bile salt output rates.

K Rahman1, R Coleman.   

Abstract

Chloroquine, when introduced into isolated perfused rat livers, caused a substantial output of cholesterol into bile, occurring after 30 min and peaking at 60 min, whereas the biliary output of acid phosphatase and beta-glucuronidase increased only after 90 min. The origins of this bile-salt-independent cholesterol are discussed.

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Year:  1987        PMID： 3689819     DOI： 10.1016/0005-2760(87)90065-8

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  2 in total

1.  Inhibition of biliary cholesterol and phospholipid secretion by cefmetazole. The role of vesicular transport and of canalicular events.

Authors:  F Cava; J Gonzalez; J M Gonzalez-Buitrago; C Muriel; R Jimenez
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

2.  Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.

Authors:  Reinout L P Roscam Abbing; Davor Slijepcevic; Joanne M Donkers; Rick Havinga; Suzanne Duijst; Coen C Paulusma; Johan Kuiper; Folkert Kuipers; Albert K Groen; Ronald P J Oude Elferink; Stan F J van de Graaf
Journal:  Hepatology       Date:  2019-08-13       Impact factor: 17.425
  2 in total

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