Literature DB >> 3689657

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.

J A Raleigh1, G G Miller, A J Franko, C J Koch, A F Fuciarelli, D A Kelly.   

Abstract

Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue.

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Year:  1987        PMID： 3689657      PMCID： PMC2001823          DOI： 10.1038/bjc.1987.213

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  31 in total

1.  An immunochemical probe for 8,5'-cycloadenosine-5'-monophosphate and its deoxy analog in irradiated nucleic acids.

Authors:  A F Fuciarelli; G G Miller; J A Raleigh
Journal:  Radiat Res       Date:  1985-12       Impact factor: 2.841

2.  Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia.

Authors:  R C Urtasun; J D Chapman; J A Raleigh; A J Franko; C J Koch
Journal:  Int J Radiat Oncol Biol Phys       Date:  1986-07       Impact factor: 7.038

3.  2-Hydroxylaminoimidazoles--unstable intermediates in the reduction of 2-nitroimidazoles.

Authors:  R A McClelland; J R Fuller; N E Seaman; A M Rauth; R Battistella
Journal:  Biochem Pharmacol       Date:  1984-01-15       Impact factor: 5.858

4.  Synthesis and in vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole.

Authors:  D C Jette; L I Wiebe; J D Chapman
Journal:  Int J Nucl Med Biol       Date:  1983

5.  Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.

Authors:  A J Varghese; S Gulyas; J K Mohindra
Journal:  Cancer Res       Date:  1976-10       Impact factor: 12.701

6.  Changes in misonidazole binding with hypoxic fraction in mouse tumors.

Authors:  D G Hirst; J L Hazlehurst; J M Brown
Journal:  Int J Radiat Oncol Biol Phys       Date:  1985-07       Impact factor: 7.038

7.  Glutathione conjugates of misonidazole.

Authors:  A J Varghese
Journal:  Biochem Biophys Res Commun       Date:  1983-05-16       Impact factor: 3.575

8.  Further characterization of 4-bromomisonidazole as a potential detector of hypoxic cells.

Authors:  J S Rasey; K A Krohn; Z Grunbaum; P J Conroy; K Bauer; R M Sutherland
Journal:  Radiat Res       Date:  1985-04       Impact factor: 2.841

9.  The detection and measurement of hypoxic cells in solid tumors.

Authors:  J D Chapman
Journal:  Cancer       Date:  1984-12-01       Impact factor: 6.860

10.  A marker for hypoxic cells in tumours with potential clinical applicability.

Authors:  J D Chapman; A J Franko; J Sharplin
Journal:  Br J Cancer       Date:  1981-04       Impact factor: 7.640
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  22 in total

1.  Early wound healing exhibits cytokine surge without evidence of hypoxia.

Authors:  Z A Haroon; J A Raleigh; C S Greenberg; M W Dewhirst
Journal:  Ann Surg       Date:  2000-01       Impact factor: 12.969

2.  Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas.

Authors:  H W M van Laarhoven; G Gambarota; A Heerschap; J Lok; I Verhagen; A Corti; S Toma; C Gallo Stampino; A van der Kogel; C J A Punt
Journal:  Invest New Drugs       Date:  2006-01       Impact factor: 3.850

Review 3.  New frontiers and developing applications in 19F NMR.

Authors:  Jian-Xin Yu; Rami R Hallac; Srinivas Chiguru; Ralph P Mason
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2012-11-02       Impact factor: 9.795

4.  A robotic system for 18F-FMISO PET-guided intratumoral pO2 measurements.

Authors:  Jenghwa Chang; Bixiu Wen; Peter Kazanzides; Pat Zanzonico; Ronald D Finn; Gabor Fichtinger; C Clifton Ling
Journal:  Med Phys       Date:  2009-11       Impact factor: 4.071

5.  Roles of HIFs and VEGF in angiogenesis in the retina and brain.

Authors:  Amir Rattner; John Williams; Jeremy Nathans
Journal:  J Clin Invest       Date:  2019-08-12       Impact factor: 14.808

6.  Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.

Authors:  Amir Rattner; Huimin Yu; John Williams; Philip M Smallwood; Jeremy Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

Review 7.  Fluorinated tracers for imaging cancer with positron emission tomography.

Authors:  Olivier Couturier; André Luxen; Jean-François Chatal; Jean-Philippe Vuillez; Pierre Rigo; Roland Hustinx
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-07-06       Impact factor: 9.236

8.  A comparative evaluation of EPR and OxyLite oximetry using a random sampling of pO(2) in a murine tumor.

Authors:  Deepti S Vikram; Anna Bratasz; Rizwan Ahmad; Periannan Kuppusamy
Journal:  Radiat Res       Date:  2007-09       Impact factor: 2.841

Review 9.  Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs).

Authors:  W A Denny; W R Wilson
Journal:  Cancer Metastasis Rev       Date:  1993-06       Impact factor: 9.264

10.  The netrin receptor UNC5B promotes angiogenesis in specific vascular beds.

Authors:  Sutip Navankasattusas; Kevin J Whitehead; Arminda Suli; Lise K Sorensen; Amy H Lim; Jia Zhao; Kye Won Park; Joshua D Wythe; Kirk R Thomas; Chi-Bin Chien; Dean Y Li
Journal:  Development       Date:  2008-02       Impact factor: 6.868
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