Literature DB >> 3689364

Inhibition of protein kinase C activity by the Leishmania donovani lipophosphoglycan.

T B McNeely1, S J Turco.   

Abstract

Purified lipophosphoglycan from Leishmania donovani was found to inhibit the activity of protein kinase C isolated from rat brain. Protein kinase C inhibition by lipophosphoglycan was continuous for 30 minutes. The glycoconjugate was a competitive inhibitor with respect to diolein, a noncompetitive inhibitor with respect to phosphatidylserine, and had no significant effect on protein kinase M and protein kinase A. A possible physiological role of lipophosphoglycan as a negative effector of protein kinase C is suggested.

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Year:  1987        PMID： 3689364     DOI： 10.1016/0006-291x(87)90926-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  21 in total

1.  Inhibition of HIV-1-mediated syncytium formation and virus replication by the lipophosphoglycan from Leishmania donovani is due to an effect on early events in the virus life cycle.

Authors:  N Genois; B Barbeau; M Olivier; M J Tremblay
Journal:  Clin Exp Immunol       Date:  2001-04       Impact factor: 4.330

2.  Heparin binds to Leishmania donovani promastigotes and inhibits protein phosphorylation.

Authors:  N K Mukhopadhyay; K Shome; A K Saha; J R Hassell; R H Glew
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

3.  Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of the protozoan parasite Leishmania.

Authors:  T B McNeely; G Rosen; M V Londner; S J Turco
Journal:  Biochem J       Date:  1989-04-15       Impact factor: 3.857

Review 4.  The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.

Authors:  P J Robinson
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

Review 5.  Biochemistry of the Leishmania species.

Authors:  R H Glew; A K Saha; S Das; A T Remaley
Journal:  Microbiol Rev       Date:  1988-12

6.  Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani.

Authors:  J R Giorgione; S J Turco; R M Epand
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

Review 7.  Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view.

Authors:  Martin Olivier; David J Gregory; Geneviève Forget
Journal:  Clin Microbiol Rev       Date:  2005-04       Impact factor: 26.132

Review 8.  The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes.

Authors:  M J McConville; M A Ferguson
Journal:  Biochem J       Date:  1993-09-01       Impact factor: 3.857

9.  c-fos and tumor necrosis factor gene expression in Leishmania donovani-infected macrophages.

Authors:  A Descoteaux; G Matlashewski
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

10.  Hydrogen peroxide-mediated toxicity for Leishmania donovani chagasi promastigotes. Role of hydroxyl radical and protection by heat shock.

Authors:  J H Zarley; B E Britigan; M E Wilson
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808
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