Literature DB >> 3688092

Effects of the antiprogesterone RU 486 on preterm birth in the rat.

R E Garfield1, J M Gasc, E E Baulieu.   

Abstract

The effects of the antiprogesterone compound RU 486 on preterm delivery, myometrial gap junctions, and plasma levels of steroid hormones were investigated in pregnant rats. Injection of RU 486 on day 16 of gestation resulted in prolonged delivery beginning after 24 hours. The preterm birth initiated by RU 486 was preceded and accompanied by the extensive development of gap junctions between myometrial cells. R 5020, but neither progesterone nor dexamethasone, prevented preterm birth and the development of gap junctions. Estrogen and progesterone levels declined after RU 486 treatment but only after a major proportion of the fetuses were delivered. This study indicates that progesterone may normally inhibit uterine contractility by suppressing the genome responsible for the expression of gap junctions.

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Year:  1987        PMID： 3688092     DOI： 10.1016/s0002-9378(87)80315-0

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN： 0002-9378            Impact factor:   8.661


  20 in total

1.  Expression and function of myometrial PSF suggest a role in progesterone withdrawal and the initiation of labor.

Authors:  Ning Xie; Liangliang Liu; Yunqing Li; Celeste Yu; Stephanie Lam; Oksana Shynlova; Martin Gleave; John R G Challis; Stephen Lye; Xuesen Dong
Journal:  Mol Endocrinol       Date:  2012-06-05

2.  Pharmacologic actions of progestins to inhibit cervical ripening and prevent delivery depend on their properties, the route of administration, and the vehicle.

Authors:  Ruben J Kuon; Shao-Qing Shi; Holger Maul; Christof Sohn; James Balducci; William L Maner; Robert E Garfield
Journal:  Am J Obstet Gynecol       Date:  2010-05       Impact factor: 8.661

Review 3.  A Cross-Species Analysis of Animal Models for the Investigation of Preterm Birth Mechanisms.

Authors:  Brian W Nielsen; Elizabeth A Bonney; Bradley D Pearce; Leah Rae Donahue; Indra Neil Sarkar
Journal:  Reprod Sci       Date:  2015-09-16       Impact factor: 3.060

Review 4.  A Critical Evaluation of Current Concepts in Cerebral Palsy.

Authors:  Joline E Brandenburg; Matthew J Fogarty; Gary C Sieck
Journal:  Physiology (Bethesda)       Date:  2019-05-01

5.  A novel optical method to assess cervical changes during pregnancy and use to evaluate the effects of progestins on term and preterm labor.

Authors:  Ruben J Kuon; Shao-Qing Shi; Holger Maul; Christof Sohn; James Balducci; Leili Shi; Robert E Garfield
Journal:  Am J Obstet Gynecol       Date:  2011-02-23       Impact factor: 8.661

6.  Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term.

Authors:  Pooja Mittal; Roberto Romero; Adi L Tarca; Juan Gonzalez; Sorin Draghici; Yi Xu; Zhong Dong; Chia-Ling Nhan-Chang; Tinnakorn Chaiworapongsa; Stephen Lye; Juan Pedro Kusanovic; Leonard Lipovich; Shali Mazaki-Tovi; Sonia S Hassan; Sam Mesiano; Chong Jai Kim
Journal:  J Perinat Med       Date:  2010-07-14       Impact factor: 1.901

7.  Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition.

Authors:  Michael A Kirby; Anne C Heuerman; Melisa Custer; Abigail E Dobyns; Ryan Strilaeff; Kathleen N Stutz; Jaclyn Cooperrider; Joseph G Elsissy; Steven M Yellon
Journal:  Reprod Sci       Date:  2016-05-27       Impact factor: 3.060

8.  Apoptosis induced by antigestagen RU486 in rat corpus luteum of pregnancy.

Authors:  C M Telleria; A A Goyeneche; J C Cavicchia; A O Stati; R P Deis
Journal:  Endocrine       Date:  2001-07       Impact factor: 3.633

Review 9.  Nongenomic action of steroids in myometrial contractility.

Authors:  M Perusquía
Journal:  Endocrine       Date:  2001-06       Impact factor: 3.633

10.  Review and Study of Uterine Bioelectrical Waveforms and Vector Analysis to Identify Electrical and Mechanosensitive Transduction Control Mechanisms During Labor in Pregnant Patients.

Authors:  R E Garfield; Lauren Murphy; Kendra Gray; Bruce Towe
Journal:  Reprod Sci       Date:  2020-10-22       Impact factor: 3.060
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