Literature DB >> 3683975

Exposure to calcium-free medium protects sensory fibers by capsaicin desensitization.

P Santicioli1, R Patacchini, C A Maggi, A Meli.   

Abstract

Capsaicin (1 microM) produces a tetrodotoxin-resistant contraction of the rat isolated urinary bladder ascribable to neuropeptide release from sensory nerves. A second application of capsaicin (1-10 microM) up to 5 h from the first one was ineffective, indicating complete desensitization. However, if the first exposure to capsaicin was made after a prolonged incubation in a Ca-free medium containing EDTA (0.1 mM), a second application of capsaicin (1 microM) was still able to induce a contraction, thus indicating protection from desensitization.

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Year:  1987        PMID： 3683975     DOI： 10.1016/0304-3940(87)90648-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons.

Authors:  P A Koplas; R L Rosenberg; G S Oxford
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

2.  Ruthenium red inhibits tail skin vasodilatation evoked by intracerebroventricular injection of capsaicin in the rat.

Authors:  M Hajós; G Jancsó; Z Mari; F Obál
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-04       Impact factor: 3.000

3.  Differential activation and desensitization of sensory neurons by resiniferatoxin.

Authors:  G Acs; T Biro; P Acs; S Modarres; P M Blumberg
Journal:  J Neurosci       Date:  1997-07-15       Impact factor: 6.167

4.  Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats.

Authors:  R J Docherty; J C Yeats; S Bevan; H W Boddeke
Journal:  Pflugers Arch       Date:  1996-04       Impact factor: 3.657

5.  The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle.

Authors:  C A Maggi; R Patacchini; P Santicioli; I T Lippe; S Giuliani; P Geppetti; E Del Bianco; S Selleri; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-08       Impact factor: 3.000

6.  Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents.

Authors:  R Patacchini; C A Maggi; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-07       Impact factor: 3.000

7.  Absorption and metabolism of capsaicinoids following intragastric administration in rats.

Authors:  J Donnerer; R Amann; R Schuligoi; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-09       Impact factor: 3.000

8.  Effect of ruthenium red on responses mediated by activation of capsaicin-sensitive nerves of the rat urinary bladder.

Authors:  C A Maggi; S Giuliani; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-11       Impact factor: 3.000

9.  Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors.

Authors:  Nikita B Ruparel; Amol M Patwardhan; Armen N Akopian; Kenneth M Hargreaves
Journal:  Pain       Date:  2007-06-27       Impact factor: 7.926
  9 in total

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