Literature DB >> 3682062

Translational requirement for La Crosse virus S-mRNA synthesis: a possible mechanism.

C Bellocq1, D Kolakofsky.   

Abstract

Ongoing protein synthesis is required for La Crosse S-mRNA synthesis in vivo, and complete S-mRNA can be made in vitro only in the presence of an active rabbit reticulocyte lysate. Using in vitro systems based on the polymerase activity of purified virions, we further support the notion that it is translation of the nascent mRNA that is required for complete transcription. Since replacement of guanosine with inosine in the nascent mRNA substitutes for the translational requirement, it appears that translation is required to prevent interactions of the nascent chain from taking place, which, if not prevented, lead to premature termination. These interactions appear to be between the nascent mRNA chain and its nucleocapsid template. A model for the translational requirement for complete S-mRNA synthesis is presented.

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Year:  1987        PMID： 3682062      PMCID： PMC256016     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Segmented genome and nucleocapsid of La Crosse virus.

Authors:  J F Obijeski; D H Bishop; E L Palmer; F A Murphy
Journal:  J Virol       Date:  1976-12       Impact factor: 5.103

2.  Translational requirement of La Crosse virus S-mRNA synthesis: in vivo studies.

Authors:  R Raju; D Kolakofsky
Journal:  J Virol       Date:  1987-01       Impact factor: 5.103

3.  Identification of four complementary RNA species in Akabane virus-infected cells.

Authors:  A K Pattnaik; G Abraham
Journal:  J Virol       Date:  1983-09       Impact factor: 5.103

4.  Early RNA synthesis in Bunyamwera virus-infected cells.

Authors:  G Abraham; A K Pattnaik
Journal:  J Gen Virol       Date:  1983-06       Impact factor: 3.891

Review 5.  Priming of influenza viral RNA transcription by capped heterologous RNAs.

Authors:  R M Krug
Journal:  Curr Top Microbiol Immunol       Date:  1981       Impact factor: 4.291

6.  Nonviral heterogeneous sequences are present at the 5' ends of one species of snowshoe hare bunyavirus S complementary RNA.

Authors:  D H Bishop; M E Gay; Y Matsuoko
Journal:  Nucleic Acids Res       Date:  1983-09-24       Impact factor: 16.971

Review 7.  Attenuation in the control of expression of bacterial operons.

Authors:  C Yanofsky
Journal:  Nature       Date:  1981-02-26       Impact factor: 49.962

8.  Characterization of La Crosse virus small-genome transcripts.

Authors:  J L Patterson; D Kolakofsky
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

9.  Transcription termination at the trp operon attenuators of Escherichia coli and Salmonella typhimurium: RNA secondary structure and regulation of termination.

Authors:  F Lee; C Yanofsky
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

10.  Use of complementary DNA oligomers to probe trp leader transcript secondary structures involved in transcription pausing and termination.

Authors:  R Fisher; C Yanofsky
Journal:  Nucleic Acids Res       Date:  1984-04-11       Impact factor: 16.971
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  18 in total

1.  Rift Valley fever virus NSs mRNA is transcribed from an incoming anti-viral-sense S RNA segment.

Authors:  Tetsuro Ikegami; Sungyong Won; C J Peters; Shinji Makino
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

2.  Bunyavirus mRNA synthesis is coupled to translation to prevent premature transcription termination.

Authors:  John N Barr
Journal:  RNA       Date:  2007-03-30       Impact factor: 4.942

3.  Germiston virus transcriptase requires active 40S ribosomal subunits and utilizes capped cellular RNAs.

Authors:  P Vialat; M Bouloy
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

4.  Storage of cellular 5' mRNA caps in P bodies for viral cap-snatching.

Authors:  M A Mir; W A Duran; B L Hjelle; C Ye; A T Panganiban
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-01       Impact factor: 11.205

5.  Mechanism of La Crosse virus inhibition by ribavirin.

Authors:  L F Cassidy; J L Patterson
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

6.  The translational requirement for complete La Crosse virus mRNA synthesis is cell-type dependent.

Authors:  R Raju; L Raju; D Kolakofsky
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

7.  Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation.

Authors:  W Reith; E Barras; S Satola; M Kobr; D Reinhart; C H Sanchez; B Mach
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

8.  Mutational analyses of the nonconserved sequences in the Bunyamwera Orthobunyavirus S segment untranslated regions.

Authors:  Anice C Lowen; Richard M Elliott
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

9.  Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis.

Authors:  A Bridgen; F Weber; J K Fazakerley; R M Elliott
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-16       Impact factor: 11.205

10.  The triplet repeats of the Sin Nombre hantavirus 5' untranslated region are sufficient in cis for nucleocapsid-mediated translation initiation.

Authors:  Mohammad A Mir; Antonito T Panganiban
Journal:  J Virol       Date:  2010-06-23       Impact factor: 5.103
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