Literature DB >> 3681312

A calcium blocking and anticholinergic agent (terodiline) in the treatment of detrusor hyperreflexia: a placebo-controlled, cross-over trial.

T Petersen1, J Jakobsen.   

Abstract

In 25 neurological patients with detrusor hyperreflexia terodiline reduced the number of total micturitions during daytime. Bladder capacity was increased and amplitude of the bladder contractions was reduced. An increase in residual urine was also observed. Mild anticholinergic side-effects were measured on pupillary motility and on heart rate variation. It is concluded that terodiline is a useful alternative in treatment of patients with detrusor hyperreflexia.

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Year:  1987        PMID: 3681312      PMCID: PMC1032460          DOI: 10.1136/jnnp.50.10.1331

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  16 in total

1.  Cholinergic mechanisms in the rat detrusor muscle.

Authors:  M Elmér
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1978

2.  Mutual role of sympathetic and parasympathetic in shaping of the pupillary reflex to light; pupillographic studies.

Authors:  O LOWENSTEIN; I E LOEWENFELD
Journal:  Arch Neurol Psychiatry       Date:  1950-09

3.  Studies on the effect and mode of action of flavoxate in human urinary bladder and sphincter.

Authors:  E Pedersen
Journal:  Urol Int       Date:  1977       Impact factor: 2.089

4.  The two-period cross-over clinical trial.

Authors:  M Hills; P Armitage
Journal:  Br J Clin Pharmacol       Date:  1979-07       Impact factor: 4.335

5.  Heart rate variation in patients treated with antidepressants. An index of anticholinergic effects?

Authors:  J Jakobsen; P Hauksson; P Vestergaard
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

6.  Neurourodynamic evaluation of voiding dysfunction in multiple sclerosis.

Authors:  T Petersen; E Pedersen
Journal:  Acta Neurol Scand       Date:  1984-06       Impact factor: 3.209

7.  Cystometric response to propantheline in detrusor hyperreflexia: therapeutic implications.

Authors:  J G Blaivas; K B Labib; S J Michalik; A A Zayed
Journal:  J Urol       Date:  1980-08       Impact factor: 7.450

8.  Anticholinergic and calcium antagonistic effects of terodiline in rabbit urinary bladder.

Authors:  S Husted; K E Andersson; L Sommer; J R Ostergaard
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1980

9.  Dynamic motor capacity in spastic paresis and its relation to prime mover dysfunction, spastic reflexes and antagonist co-activation.

Authors:  E Knutsson; A Mårtensson
Journal:  Scand J Rehabil Med       Date:  1980

10.  Counting of flexor spasms.

Authors:  E Pedersen; B Klemar; J Tørring
Journal:  Acta Neurol Scand       Date:  1979-09       Impact factor: 3.209

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  3 in total

1.  Terodiline causes polymorphic ventricular tachycardia due to reduced heart rate and prolongation of QT interval.

Authors:  D A Stewart; J Taylor; S Ghosh; G J Macphee; I Abdullah; J M McLenachan; D J Stott
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence.

Authors:  H D Langtry; D McTavish
Journal:  Drugs       Date:  1990-11       Impact factor: 9.546

3.  Tolerability and steady-state pharmacokinetics of terodiline and its main metabolites in elderly patients with urinary incontinence.

Authors:  B Hallén; S Bogentoft; S Sandquist; S Strömberg; G Setterberg; E Ryd-Kjellén
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

  3 in total

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