Literature DB >> 3681287

Amino acid levels in human CSF after generalized seizure.

A Pitkänen1, P J Riekkinen, T Halonen, A Ylinen, T Ruutiainen, M Lehtinen.   

Abstract

We studied the possible role of excitatory and inhibitory amino acids and their balance during generalized convulsions. The levels of amino acids in postictal cerebrospinal fluid (CSF) were compared with amino acid concentrations in interictal CSF of ten patients with generalized tonic-clonic convulsions. Glu, Gln, Asp, Asn, Tau, Gly, total GABA (t-GABA), free GABA (f-GABA), and homocarnosine levels and Glu/Gln, Asp/Asn, t-GABA/Glu, f-GABA/Glu, f-GABA/Asp, and Glu/Asp ratios were similar in both samples (Student's paired t-test). Our results suggest that in humans possible changes in amino acids in brain tissue during the ictal stage are not reflected in the lumbar CSF.

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Year:  1987        PMID： 3681287     DOI： 10.1007/bf01253605

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  13 in total

Review 1.  Amino acid transport mechanisms of the cerebrospinal fluid.

Authors:  A V Lorenzo
Journal:  Fed Proc       Date:  1974-09

2.  Free amino acids in the cerebrospinal fluid of epileptic subjects.

Authors:  R Mutani; F Monaco; L Durelli; M Delsedime
Journal:  Epilepsia       Date:  1974-12       Impact factor: 5.864

3.  Cerebrospinal fluid flow and iodide 131 transport in the spinal subarachnoid space.

Authors:  R M Post; F H Allen; A K Ommaya
Journal:  Life Sci       Date:  1974-05-16       Impact factor: 5.037

4.  Amino acids in rat striatal dialysates: methodological aspects and changes after electroconvulsive shock.

Authors:  J Korf; K Venema
Journal:  J Neurochem       Date:  1985-11       Impact factor: 5.372

5.  Amino acid metabolism in the brain with convulsive disorders. Part 3: Free amino acid patterns in cerebrospinal fluid in infants and children with convulsive disorders.

Authors:  T Honda
Journal:  Brain Dev       Date:  1984       Impact factor: 1.961

6.  Cerebrospinal fluid amino acid and monoamine metabolite levels of Papio papio: correlation with photosensitivity.

Authors:  K G Lloyd; B Scatton; C Voltz; P Bryere; A Valin; R Naquet
Journal:  Brain Res       Date:  1986-01-22       Impact factor: 3.252

7.  Amino acid abnormalities in epileptogenic foci.

Authors:  T L Perry; S Hansen
Journal:  Neurology       Date:  1981-07       Impact factor: 9.910

8.  Feline generalized penicillin epilepsy: changes of glutamic acid and taurine parallel the progressive increase in excitability of the cortex.

Authors:  N M van Gelder; I Siatitsas; C Ménini; P Gloor
Journal:  Epilepsia       Date:  1983-04       Impact factor: 5.864

9.  Changes in regional brain levels of amino acid putative neurotransmitters after prolonged treatment with the anticonvulsant drugs diphenylhydantoin, phenobarbitone, sodium valproate, ethosuximide, and sulthiame in the rat.

Authors:  P N Patsalos; P T Lascelles
Journal:  J Neurochem       Date:  1981-02       Impact factor: 5.372

10.  Altered amino acid levels in multiply affected sibships with seizures.

Authors:  J L Haines; S S Rich; M Y Tsai; V E Anderson
Journal:  Epilepsia       Date:  1985 Nov-Dec       Impact factor: 5.864
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3.  Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients.

Authors:  A Pitkänen; R Matilainen; T Halonen; R Kutvonen; P Hartikainen; P Riekkinen
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

4.  A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by (1)H NMR-Based Metabonomics and the NF-κB Pathway.

Authors:  Yuanyan Liu; Zeqin Lian; Haibo Zhu; Yinghong Wang; Shishan Yu; Tingting Chen; Jing Qu; Jianbei Li; Shuanggang Ma; Xianhong Chen
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  4 in total

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