Granulosa cell metabolism and the assessment of oocyte quality in IVF.

The progesterone production of the granulosa cells of the cumulus-oocyte complex correlates very well with the cleavage potential of embryos in an IVF system. The method is simple and can be easily performed by any laboratory associated with IVF. Furthermore, high intratubal progesterone levels in the immediate post-ovulatory period are probably important in prolonging the intra-ampullary residence of the oocyte or embryo until the uterine endometrium is optimal for implantation.