Literature DB >> 3680023

Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor KS-619-1.

T Yasuzawa1, M Yoshida, K Shirahata, H Sano.   

Abstract

The structure of KS-619-1, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 8,13-dioxo-3-(2-oxopropyl)-5,6,8,13-tetrahydro-1,7,9,11- tetrahydroxybenz[a]naphtacene-2-carboxylic acid by spectral studies of KS-619-1 and its methyl derivative.

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Year:  1987        PMID： 3680023     DOI： 10.7164/antibiotics.40.1111

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola.

Authors:  Ratnakar N Asolkar; Theo N Kirkland; Paul R Jensen; William Fenical
Journal:  J Antibiot (Tokyo)       Date:  2009-11-20       Impact factor: 2.649

2.  Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis.

Authors:  Zhenjian Lin; Malcolm M Zachariah; Lenny Marett; Ronald W Hughen; Russell W Teichert; Gisela P Concepcion; Margo G Haygood; Baldomero M Olivera; Alan R Light; Eric W Schmidt
Journal:  J Nat Prod       Date:  2014-05-01       Impact factor: 4.050

3.  Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus.

Authors:  Torben Hofeditz; Claudia Eva-Maria Unsin; Jutta Wiese; Johannes F Imhoff; Wolfgang Wohlleben; Stephanie Grond; Tilmann Weber
Journal:  Antibiotics (Basel)       Date:  2018-06-28

4.  Novel Fredericamycin Variant Overproduced by a Streptomycin-resistant Streptomyces albus subsp. chlorinus Strain.

Authors:  Marta Rodríguez Estévez; Maksym Myronovskyi; Birgit Rosenkränzer; Thomas Paululat; Lutz Petzke; Jeanette Ristau; Andriy Luzhetskyy
Journal:  Mar Drugs       Date:  2020-05-28       Impact factor: 5.118
  4 in total

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