Literature DB >> 3680009

Metabolic products of microorganisms. 239. Bacimethrin isolated from Streptomyces albus identification, derivatives, synthesis and biological properties.

H Drautz1, W Messerer, H Zähner, S Breiding-Mack, A Zeeck.   

Abstract

Bacimethrin (1), known as a thiamine antagonist produced by Bacillus megatherium, was isolated from Streptomyces albus and has been further characterized by NMR spectra and acetylation. A new easy three step synthesis for 1 is described. The biological activity of 1, and its mode of action were discussed. There are indications that bacimethrin inhibits the phosphorylation of 4-amino-5-hydroxymethyl-2-methylpyrimidine (Pyr-OH) during thiamine biosynthesis.

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Year:  1987        PMID： 3680009     DOI： 10.7164/antibiotics.40.1431

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Action of the thiamine antagonist bacimethrin on thiamine biosynthesis.

Authors:  J L Zilles; L R Croal; D M Downs
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

2.  Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin.

Authors:  Natalia S Nemeria; Brateen Shome; Alicia A DeColli; Kathryn Heflin; Tadhg P Begley; Caren Freel Meyers; Frank Jordan
Journal:  Biochemistry       Date:  2016-02-08       Impact factor: 3.162

3.  Biosynthesis of a thiamin antivitamin in Clostridium botulinum.

Authors:  Lisa E Cooper; Seán E O'Leary; Tadhg P Begley
Journal:  Biochemistry       Date:  2014-04-01       Impact factor: 3.162

4.  Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry.

Authors:  Gong Zhao; Geng Wu; Yan Zhang; Guang Liu; Tiesheng Han; Zixin Deng; Xinyi He
Journal:  Nucleic Acids Res       Date:  2014-06-11       Impact factor: 16.971

5.  Essential Metabolic Routes as a Way to ESKAPE From Antibiotic Resistance.

Authors:  Angélica Luana C Barra; Lívia de Oliveira C Dantas; Luana Galvão Morão; Raíssa F Gutierrez; Igor Polikarpov; Carsten Wrenger; Alessandro S Nascimento
Journal:  Front Public Health       Date:  2020-02-28
  5 in total

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