| Literature DB >> 3677411 |
F Vandenesch1, F Baklouti, A Francina, C Vianey-Liaud, A Bertrand, C Le Dévéhat, J Delaunay.
Abstract
Three independent cases of Hemoglobin J-Baltimore(beta 16(A13)Gly----Asp) were detected through the assay of HbA1c in diabetic patients. Using chromatography on Bio-Rex 70 resin, one large peak replaced the usually well resolved peaks of HbA1a + b and HbA1c. The species that overlapped the latter fractions was identified as HbJ1c. HbJ-Baltimore itself was identified using HPLC of the beta-chain tryptic peptides. This observation emphasizes the errors that hemoglobin variants may introduce in the assay of HbA1c.Entities:
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Year: 1987 PMID： 3677411 DOI： 10.1016/0009-8981(87)90280-4
Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786