Literature DB >> 3677280

Effect of chlorpromazine on drug absorption and gastric emptying in man.

O U Petring1, B Adelhøj, M Ibsen, H E Poulsen.   

Abstract

In a double-blind study the effect of a single IV dose (25 mg) of chlorpromazine on gastric emptying, as determined by the rate of paracetamol absorption, was measured in seven healthy volunteers. Each volunteer acted as his/her own control. There was no significant difference between the maximum paracetamol concentration, the time to reach the plasma maximum concentration, and the area under the plasma concentration time curve from 0-120 minutes on the two occasions, indicating unchanged gastric emptying after administration of chlorpromazine.

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Year:  1987        PMID: 3677280     DOI: 10.1007/BF03010511

Source DB:  PubMed          Journal:  Can J Anaesth        ISSN: 0832-610X            Impact factor:   5.063


  11 in total

1.  Determination of paracetamol and its metabolites in urine by high-performance liquid chromatography using reversed-phase bonded supports.

Authors:  J H Knox; J Jurand
Journal:  J Chromatogr       Date:  1977-11-11

2.  The dependence of paracetamol absorption on the rate of gastric emptying.

Authors:  R C Heading; J Nimmo; L F Prescott; P Tothill
Journal:  Br J Pharmacol       Date:  1973-02       Impact factor: 8.739

Review 3.  Effect of anaesthesia on gastric motility and emptying.

Authors:  W S Nimmo
Journal:  Br J Anaesth       Date:  1984-01       Impact factor: 9.166

Review 4.  Nausea and vomiting.

Authors:  R S Clarke
Journal:  Br J Anaesth       Date:  1984-01       Impact factor: 9.166

5.  Kinetics of acetaminophen absorption and gastric emptying in man.

Authors:  J A Clements; R C Heading; W S Nimmo; L F Prescott
Journal:  Clin Pharmacol Ther       Date:  1978-10       Impact factor: 6.875

6.  Medical management of chronic cancer pain.

Authors:  D S Shimm; G L Logue; A A Maltbie; S Dugan
Journal:  JAMA       Date:  1979-06-01       Impact factor: 56.272

7.  Pharmacological effects on gastric emptying following laparotomy in the rat.

Authors:  L Rentzhog; S Wikström
Journal:  Acta Chir Scand       Date:  1975

8.  Buprenorphine delays drug absorption and gastric emptying in man.

Authors:  B Adelhøj; O U Petring; M Ibsen; J Brynnum; H E Poulsen
Journal:  Acta Anaesthesiol Scand       Date:  1985-08       Impact factor: 2.105

9.  Postoperative gastric emptying.

Authors:  D M Ingram; H J Sheiner
Journal:  Br J Surg       Date:  1981-08       Impact factor: 6.939

Review 10.  The control of chemotherapy-induced emesis.

Authors:  L J Seigel; D L Longo
Journal:  Ann Intern Med       Date:  1981-09       Impact factor: 25.391

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