| Literature DB >> 3676753 |
P N Riskind1, J M Kolodny, P R Larsen.
Abstract
The brain topographical distribution of type II 5'-monodeiodinase (5'D-II), which converts thyroxine (T4) to triiodothyronine (T3), was studied in euthyroid and hypothyroid rats. Low levels of 5'D-II activity were detected in the median eminence, but not in any other brain regions of euthyroid rats. The arcuate nucleus and median eminence were also the sites of highest 5'D-II activity in brains of hypothyroid rats. Under these conditions, the paraventricular nucleus contained almost no detectable 5'D-II, while intermediate enzyme activity was present in other medial basal hypothalamic sites.Entities:
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Year: 1987 PMID： 3676753 DOI： 10.1016/0006-8993(87)90260-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252