Literature DB >> 3676603

A study on the effect of a single dose of tamoxifen on uterine hyperaemia and growth in the rat.

K Marshall1, J Senior.   

Abstract

1 The effect of a single subcutaneous dose of tamoxifen on the rat uterotrophic response was investigated. 2 The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3 Tamoxifen or its metabolites proved to be capable of eliciting a uterotrophic response of 35-42 days duration. The changes seen in uterine blood flow and weight are discussed in relation to oestrogen receptor distribution.

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Year:  1987        PMID: 3676603      PMCID: PMC1853645          DOI: 10.1111/j.1476-5381.1987.tb11339.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  28 in total

1.  The role of eosinophil receptors in the non-genomic response to oestrogens in the uterus.

Authors:  A Tchernitchin
Journal:  J Steroid Biochem       Date:  1979-07       Impact factor: 4.292

2.  Estrogen receptor translocation and replenishment by the antiestrogen tamoxifen.

Authors:  Y Koseki; D T Zava; G C Chamness; W L McGuire
Journal:  Endocrinology       Date:  1977-10       Impact factor: 4.736

3.  Modification of oestrogen-induced uterine hyperaemia by drugs in the ovariectomized rat.

Authors:  S Phaily; J Senior
Journal:  J Reprod Fertil       Date:  1978-05

4.  Antiestrogen pharmacology and mechanism of action.

Authors:  B S Katzenellenbogen; M A Miller; R L Eckert; K Sudo
Journal:  J Steroid Biochem       Date:  1983-07       Impact factor: 4.292

5.  Relationships between type I and II estradiol binding sites and estrogen induced responses.

Authors:  J H Clark; B M Markaverich
Journal:  J Steroid Biochem       Date:  1981-12       Impact factor: 4.292

6.  High-affinity anti-oestrogen binding site distinct from the oestrogen receptor.

Authors:  R L Sutherland; L C Murphy; M San Foo; M D Green; A M Whybourne; Z S Krozowski
Journal:  Nature       Date:  1980-11-20       Impact factor: 49.962

7.  Hypothalamic, pituitary and uterine cytoplasmic and nuclear oestrogen receptors and their relationship to the serum concentration of tamoxifen and its metabolite, 4-hydroxytamoxifen, in the ovariectomized rat.

Authors:  S P Bowman; A Leake; I D Morris
Journal:  J Endocrinol       Date:  1982-08       Impact factor: 4.286

8.  Direct and reversible inhibition of estradiol-stimulated prolactin synthesis by antiestrogens in vitro.

Authors:  M E Lieberman; V C Jordan; M Fritsch; M A Santos; J Gorski
Journal:  J Biol Chem       Date:  1983-04-25       Impact factor: 5.157

9.  Dose dependent modulation of receptor dynamics and uterine growth in immature rat by estradiol: importance of an additional nuclear binding at 24 hr for long-term (72 hr) uterine growth.

Authors:  A K Agarwal; S Durani; B S Setty
Journal:  Endokrinologie       Date:  1982-06

10.  Estrogen receptor translocation and replenishment in rat hypothalamus and pituitary gland after the application of catecholestrogen or nonsteroidal antiestrogen.

Authors:  J Kirchhoff; B Hoffmann; R Ghraf
Journal:  J Steroid Biochem       Date:  1983-05       Impact factor: 4.292

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  4 in total

1.  Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists.

Authors:  M B Kerr; K Marshall; J Senior
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

2.  The effects of thromboxane receptor antagonists on oestrogen-induced uterotrophic responses in the spontaneously hypertensive rat.

Authors:  M B Kerr; K Marshall; J Senior
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

3.  The effect of a single dose of oestradiol on tamoxifen-induced uterine hyperaemia and growth in the rat.

Authors:  K Marshall; J Senior
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

4.  Endometrial Surveillance in Tamoxifen and Letrozole Treated Breast Cancer Patients.

Authors:  Adhari AlZaabi; Hafsa AlAmri; Ghadeer ALAjmi; Manhal Allawati; Fatema Muhanna; Ruqaia Alabri; Fatema AlBusaidi; Shaima AlGhafri; Abdulrahman A Al-Mirza; Khalid Al Baimani
Journal:  Cureus       Date:  2021-11-30
  4 in total

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