Literature DB >> 3675593

Histamine stimulates inositol phosphate accumulation via the H1-receptor in cultured human endothelial cells.

W W Lo1, T P Fan.   

Abstract

The effects of histamine on [3H]inositol phosphate ([3H]IP) accumulation was examined in the presence of lithium in [3H]inositol-prelabelled human umbilical vein endothelial cells. Histamine stimulated total [3H]IP formation in a dose-dependent manner with a half-maximal value (EC50) of around 1-2 X 10(-6) M. Mepyramine, but not cimetidine, completely abolished the histamine response indicating that activation of phosphoinositide hydrolysis is mediated via H1-receptors. These data are the first to suggest that activation of inositol lipid hydrolysis is the underlying transmembrane signalling mechanism histamine H1-receptors employ in mediating various endothelial cell functions.

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Year:  1987        PMID： 3675593     DOI： 10.1016/0006-291x(87)91074-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  Up-regulation of thrombomodulin by activation of histamine H1-receptors in human umbilical-vein endothelial cells in vitro.

Authors:  K Hirokawa; N Aoki
Journal:  Biochem J       Date:  1991-06-15       Impact factor: 3.857

2.  Beta-adrenoceptor stimulation inhibits histamine-stimulated inositol phospholipid hydrolysis in bovine tracheal smooth muscle.

Authors:  I P Hall; S J Hill
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

3.  Modification by some antagonists of the shape changes of venous endothelial cells in response to inflammatory agents in vitro.

Authors:  A M Northover
Journal:  Agents Actions       Date:  1990-03

4.  Regulation of endothelial tissue plasminogen activator and plasminogen activator inhibitor type 1 synthesis by diacylglycerol, phorbol ester, and thrombin.

Authors:  J Grulich-Henn; G Müller-Berghaus
Journal:  Blut       Date:  1990-07

5.  5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells.

Authors:  C Ullmer; H G Boddeke; K Schmuck; H Lübbert
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

6.  Histamine, ZO-1 and increased blood-retinal barrier permeability in diabetic retinopathy.

Authors:  T W Gardner
Journal:  Trans Am Ophthalmol Soc       Date:  1995

7.  Temporal changes in the calcium-force relation during histamine-induced contractions of strips of the coronary artery of the pig.

Authors:  K Hirano; H Kanaide; S Abe; M Nakamura
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

8.  Dissociation of phosphoinositide hydrolysis and positive inotropic effect of histamine mediated by H1-receptors in guinea-pig left atria.

Authors:  Y Hattori; M Endou; M Shirota; M Kanno
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-08       Impact factor: 3.000

9.  Agonist-stimulated divalent cation entry into single cultured human umbilical vein endothelial cells.

Authors:  R Jacob
Journal:  J Physiol       Date:  1990-02       Impact factor: 5.182

10.  Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells.

Authors:  G McCreath; I P Hall; S J Hill
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739
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