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Literature DB >> 367473

Biological and clinical relevance of human macrophage migration inhibitory factor (MIF).

Abstract

The first isolation and characterization of a lymphokine, the human MIF (MSF), and the availability of a specific MIF (MSF)-antibody provide an opportunity to establish a new parameter for detection of cellular immune mechanisms in various clinical situations. The precise estimation of quantitative amounts of MIF by sensitive immunochemical techniques could gain new insights into the pathogenesis of a number of clinical disorders. In addition, the exact detection of quantitative amounts of MIF in body fluids could have prognostic value.

Entities: Gene Species

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Year: 1979 PMID： 367473 DOI： 10.1007/bf01007950

Source DB: PubMed Journal: Blut ISSN： 0006-5242

53 in total

2. Flow-cytometric measurements of the transmembrane potential, the surface charge density and the phagocytic activity of Guinea pig macrophages after incubation with lymphokines.

Authors: G Valet; H L Jenssen; M Krefft; G Ruhenstroth-Bauer
Journal: Blut Date: 1981-06

2 in total

Biological and clinical relevance of human macrophage migration inhibitory factor (MIF).

Review 1. Macrophage-lymphocyte interaction and antigen recognition.

2. Migration inhibitory activity in serum and cell supernatants in patients with Sezary syndrome.

3. Leucocyte-migration inhibition induced by IgG in rheumatoid arthritis.

4. Transfer factor therapy in a patient with progressive primary tuberculosis.

5. Induction of delayed hypersensitivity to influenza and mumps viruses in mice.

6. Inhibition of target cell proliferation by supernatants from cultures of human peripheral lymphocytes.

7. Detection in vitro of cellular hypersensitivity to drugs.

8. Lymphocyte stimulation: transfer of cellular hypersensitivity to antigen in vitro.

9. "Lymphokines": non-antibody mediators of cellular immunity generated by lymphocyte activation.

10. Requirement for alpha-L-fucose on the macrophage membrane receptor for MIF.

1. Cyclosporin A: pharmacologic activity on the immune system and effects in clinical organ transplantation.

2. Flow-cytometric measurements of the transmembrane potential, the surface charge density and the phagocytic activity of Guinea pig macrophages after incubation with lymphokines.