Literature DB >> 367445

Methionyl-tRNA synthetase of Escherichia coli. A zinc metalloprotein.

L H Posorske, M Cohn, N Yanagisawa, D S Auld.   

Abstract

The native dimeric form of methionyl-tRNA synthetase of Escherichia coli contains two zinc atoms per dimer, one per subunit. The bound zinc is retained upon trypsin modification which yields a monomer with one zinc atom. The enzymatic activity of both the dimeric forms is reversibly inhibited by 1,10-phenanthroline but not by its non-chelating analogues. In addition, the native enzyme binds two Mn2+ per dimer with a binding constant of approx. 70 micron but no binding is observed with the trypsin-modified monomer.

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Year:  1979        PMID： 367445     DOI： 10.1016/0005-2795(79)90491-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition.

Authors:  W T Miller; P Schimmel
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

2.  Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences.

Authors:  P F Searle
Journal:  Nucleic Acids Res       Date:  1990-08-25       Impact factor: 16.971

3.  Multiple proteins bind to the P2 promoter region of the zein gene pMS1 of maize.

Authors:  U G Maier; K D Grasser; M M Haass; G Feix
Journal:  Mol Gen Genet       Date:  1990-04

4.  The sarcomeric actin CArG-binding factor is indistinguishable from the c-fos serum response factor.

Authors:  L M Boxer; R Prywes; R G Roeder; L Kedes
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

5.  Properties of a CCAAT box-binding protein.

Authors:  R A Hooft van Huijsduijnen; J Bollekens; A Dorn; C Benoist; D Mathis
Journal:  Nucleic Acids Res       Date:  1987-09-25       Impact factor: 16.971

6.  Heavy metal ions in transcription factors from HeLa cells: Sp1, but not octamer transcription factor requires zinc for DNA binding and for activator function.

Authors:  G Westin; W Schaffner
Journal:  Nucleic Acids Res       Date:  1988-07-11       Impact factor: 16.971

7.  Metal-binding site in a class I tRNA synthetase localized to a cysteine cluster inserted into nucleotide-binding fold.

Authors:  J A Landro; P Schimmel
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

8.  The role of zinc in 5',5'-diadenosine tetraphosphate production by aminoacyl-transfer RNA synthetases.

Authors:  S Blanquet; P Plateau; A Brevet
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

9.  A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.

Authors:  G Westin; W Schaffner
Journal:  EMBO J       Date:  1988-12-01       Impact factor: 11.598
  9 in total

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