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Literature DB >> 367407

Altered elimination of desmethyldiazepam in the elderly.

U Klotz, P Müller-Seydlitz.

Abstract

Entities: Chemical

Mesh：

Substances：
Nordazepam
Diazepam

Year: 1979 PMID： 367407 PMCID： PMC1429605 DOI： 10.1111/j.1365-2125.1979.tb00908.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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9 in total

1. Effects of aging and liver disease on disposition of lorazepam.

Authors: J W Kraus; P V Desmond; J P Marshall; R F Johnson; S Schenker; G R Wilkinson
Journal: Clin Pharmacol Ther Date: 1978-10 Impact factor: 6.875

2. Absorption and disposition of chlordiazepoxide in young and elderly male volunteers.

Authors: R I Shader; D J Greenblatt; J S Harmatz; K Franke; J Koch-Weser
Journal: J Clin Pharmacol Date: 1977 Nov-Dec Impact factor: 3.126

3. Pharmacology of the metabolites of chlordiazepoxide and diazepam.

Authors: L O Randall; C L Scheckel; R F Banziger
Journal: Curr Ther Res Clin Exp Date: 1965-09

4. Time integral of drug concentration in the central (plasma) compartment.

Authors: W J Westlake
Journal: J Pharm Sci Date: 1970-05 Impact factor: 3.534

5. Metabolism of diazepam in rat, dog, and man.

Authors: M A Schwartz; B A Koechlin; E Postma; S Palmer; G Krol
Journal: J Pharmacol Exp Ther Date: 1965-09 Impact factor: 4.030

6. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

Authors: U Klotz; G R Avant; A Hoyumpa; S Schenker; G R Wilkinson
Journal: J Clin Invest Date: 1975-02 Impact factor: 14.808

7. Comparison of the pharmacokinetics of diazepam after single and subchronic doses.

Authors: U Klotz; K H Antonin; P R Bieck
Journal: Eur J Clin Pharmacol Date: 1976-06-15 Impact factor: 2.953

8. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis.

Authors: H J Shull; G R Wilkinson; R Johnson; S Schenker
Journal: Ann Intern Med Date: 1976-04 Impact factor: 25.391

9. Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium).

Authors: R K Roberts; G R Wilkinson; R A Branch; S Schenker
Journal: Gastroenterology Date: 1978-09 Impact factor: 22.682

9 in total

16 in total

Review 1. Hepatic drug metabolism and aging.

Authors: C Durnas; C M Loi; B J Cusack
Journal: Clin Pharmacokinet Date: 1990-11 Impact factor: 6.447

Altered elimination of desmethyldiazepam in the elderly.

1. Effects of aging and liver disease on disposition of lorazepam.

2. Absorption and disposition of chlordiazepoxide in young and elderly male volunteers.

3. Pharmacology of the metabolites of chlordiazepoxide and diazepam.

4. Time integral of drug concentration in the central (plasma) compartment.

5. Metabolism of diazepam in rat, dog, and man.

6. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

7. Comparison of the pharmacokinetics of diazepam after single and subchronic doses.

8. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis.

9. Effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (librium).

Review 1. Hepatic drug metabolism and aging.

Review 2. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

3. Pharmacokinetics of pentopril in the elderly.

4. Benzodiazepines: clinical pharmacology and therapeutic use.

5. Pharmacokinetics of brotizolam in the elderly.

6. Effect of age and liver cirrhosis on the pharmacokinetics of nitrazepam.

Review 7. Managing alcohol withdrawal in the elderly.

8. Clobazam kinetics in the elderly.

9. Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate.

10. Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations.