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Literature DB >> 3673344

Uptake of selected antibacterial agents in Mycobacterium avium.

H L David¹, S Clavel-Seres, F Clement, K S Goh.

Abstract

The antibacterial action of 64 drugs against Mycobacterium avium ATCC 15769 was screened in Middlebrook 7H9 liquid medium. The most active drugs were ansamycin, rifampicin, clofazimine, and pristinamycin. The antibacterial action of the selected drugs was confirmed by testing clinical isolates on Middlebrook 7H10 agar medium. The antibacterial actions were not related with the hydrophobicities and molecular weights of the drugs. However, all the active drugs were highly hydrophobic molecules of low polarity. These drugs dissolved into the lipids forming the outer layers of the bacterial envelope and they appeared to interact with the surface amphiphils.

Entities: Chemical Species

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Year: 1987 PMID： 3673344

Source DB: PubMed Journal: Zentralbl Bakteriol Mikrobiol Hyg A ISSN： 0176-6724

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Cited

7 in total

1. Action of 1-isonicotinyl-2-palmitoyl hydrazine against the Mycobacterium avium complex and enhancement of its activity by m-fluorophenylalanine.

Authors: N Rastogi; K S Goh
Journal: Antimicrob Agents Chemother Date: 1990-11 Impact factor: 5.191

2. Extracellular and intracellular activities of clarithromycin used alone and in association with ethambutol and rifampin against Mycobacterium avium complex.

Authors: N Rastogi; V Labrousse
Journal: Antimicrob Agents Chemother Date: 1991-03 Impact factor: 5.191

3. Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis.

Authors: N Rastogi; K S Goh; H L David
Journal: Antimicrob Agents Chemother Date: 1990-05 Impact factor: 5.191

4. Liposome encapsulation of clofazimine reduces toxicity in vitro and in vivo and improves therapeutic efficacy in the beige mouse model of disseminated Mycobacterium avium-M. intracellulare complex infection.

Authors: R T Mehta
Journal: Antimicrob Agents Chemother Date: 1996-08 Impact factor: 5.191

Uptake of selected antibacterial agents in Mycobacterium avium.

1. Action of 1-isonicotinyl-2-palmitoyl hydrazine against the Mycobacterium avium complex and enhancement of its activity by m-fluorophenylalanine.

2. Extracellular and intracellular activities of clarithromycin used alone and in association with ethambutol and rifampin against Mycobacterium avium complex.

3. Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis.

4. Liposome encapsulation of clofazimine reduces toxicity in vitro and in vivo and improves therapeutic efficacy in the beige mouse model of disseminated Mycobacterium avium-M. intracellulare complex infection.

5. Intracellular accumulation of norfloxacin in Mycobacterium smegmatis.

6. Permeability barrier to hydrophilic solutes in Mycobacterium chelonei.

7. Hitting bacteria at the heart of the central dogma: sequence-specific inhibition.