Literature DB >> 3672546

LD50 determination: objections to the method of Beccari as modified by Molinengo.

C Sevcik1.   

Abstract

The efficiency of the method of Beccari as modified by Molinengo is compared with the sequential technique of Dixon and Mood. It is concluded that the sequential technique is less constrained, gives estimates that are less disperse and is simpler to analyze statistically than the regression of Beccari-Molinengo. Both techniques are comparable in the number of animals required, as well as in the time invested in each assay.

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Year:  1987        PMID: 3672546     DOI: 10.1016/0041-0101(87)90128-0

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  2 in total

1.  Core body temperature as adjunct to endpoint determination in murine median lethal dose testing of rattlesnake venom.

Authors:  Charles C Cates; James G McCabe; Gregory W Lawson; Marcelo A Couto
Journal:  Comp Med       Date:  2014-12       Impact factor: 0.982

2.  Differences in venom toxicity and antigenicity between females and males Tityus nororientalis (Buthidae) scorpions.

Authors:  Leonardo De Sousa; Adolfo Borges; Aleikar Vásquez-Suárez; Huub Jm Op den Camp; Rosa I Chadee-Burgos; Mirna Romero-Bellorín; Jorge Espinoza; Leonardo De Sousa-Insana; Oscar Pino-García
Journal:  J Venom Res       Date:  2010-10-21
  2 in total

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