Literature DB >> 3671351

Neutrophil responsiveness to chemoattractant tripeptide in rheumatoid arthritis.

R A Turner1, J A Johnson, S R Turner.   

Abstract

Neutrophils isolated from medication-free rheumatoid arthritis (RA) patients were assayed for responsiveness to the bacterial chemoattractant tripeptide formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). Rheumatoid arthritis neutrophil preparations contained significantly lower percentages of rapidly migrating cells. This relative hyporesponsiveness of RA neutrophils was related to impaired sensing of chemotactic gradients. Rheumatoid neutrophil abnormalities in sensing of and responding to chemotactic gradients were not associated with resting or f-Met-Leu-Phe-induced changes in arachidonic acid metabolism.

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Year:  1987        PMID： 3671351     DOI： 10.3181/00379727-186-42591

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  6 in total

1.  Chemotaxis and chemiluminescence responses of synovial fluid polymorphonuclear leucocytes during acute reactive arthritis.

Authors:  M Leirisalo-Repo; A Lauhio; H Repo
Journal:  Ann Rheum Dis       Date:  1990-08       Impact factor: 19.103

2.  Migratory activity of blood polymorphonuclear leukocytes during juvenile rheumatoid arthritis, demonstrated with a new whole-blood membrane filter assay.

Authors:  G Egger; C Klemt; S Spendel; W Kaulfersch; H Kenzian
Journal:  Inflammation       Date:  1994-08       Impact factor: 4.092

3.  Evaluation of Tenidap (CP-66,248) on human neutrophil arachidonic acid metabolism, chemotactic potential and clinical efficacy in the treatment of rheumatoid arthritis.

Authors:  D M Smith; J A Johnson; R Loeser; R A Turner
Journal:  Agents Actions       Date:  1990-08

4.  Functions of polymorphonuclear leukocytes in early rheumatoid arthritis.

Authors:  M Leirisalo-Repo; L Paimela; S Koskimies; H Repo
Journal:  Inflammation       Date:  1993-08       Impact factor: 4.092

5.  Tumor necrosis factor priming of peripheral blood neutrophils from rheumatoid arthritis patients.

Authors:  I C Kowanko; A Ferrante; G Clemente; P P Youssef; M Smith
Journal:  J Clin Immunol       Date:  1996-07       Impact factor: 8.317

6.  Abnormal directed migration of blood polymorphonuclear leukocytes in rheumatoid arthritis. Potential role in increased susceptibility to bacterial infections.

Authors:  F Aglas; J Hermann; G Egger
Journal:  Mediators Inflamm       Date:  1998       Impact factor: 4.711
  6 in total

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