| Literature DB >> 3669911 |
A Cuéllar1, A Cárabez, E Chávez.
Abstract
Ca2+ energy-coupled transport was analized in adrenal cortex mitochondria using the sesquiterpenic drug perezone. Perezone promotes Ca2+ efflux by inducing collapse of the membrane potential and oxidation of pyridine nucleotides. The effect of perezone on mitochondrial Ca2+ release follows a dose-response relationship and is dependent of the reduction of the drug. These data suggest that perezone may produce a cytotoxic effect through an impairment in Ca2+ homeostasis.Entities:
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Year: 1987 PMID： 3669911 DOI： 10.1016/0024-3205(87)90479-6
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037