Literature DB >> 3668304

Interferon treatment of human stomach and breast carcinoma xenografts in nude mice.

Y Kimoto1, M Fujita, T Taguchi.   

Abstract

Comparative effects of natural and recombinant interferons (IFNs)-alpha and -beta on xenografted human gastric and breast carcinoma lines in nude mice were studied. The lines were sensitive to IFNs. The breast carcinoma lines were more sensitive than the gastric carcinoma lines to IFNs. Natural IFN-beta was more effective than the other three IFNs on the gastric carcinoma lines. One breast carcinoma line was more sensitive to IFN-alpha whereas the other was more sensitive to IFN-beta. Large doses and frequent injections of IFNs were necessary for optimal effectiveness.

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Year:  1987        PMID： 3668304     DOI： 10.1089/jir.1987.7.345

Source DB:  PubMed          Journal:  J Interferon Res        ISSN： 0197-8357


  2 in total

1.  Antiproliferative effects of natural interferon beta alone and in combination with natural interferon gamma on human breast carcinomas in nude mice.

Authors:  L Ozzello; D V Habif; C M DeRosa
Journal:  Breast Cancer Res Treat       Date:  1990-09       Impact factor: 4.872

2.  Inhibition of hormone-dependent and independent breast cancer cell growth in vivo and in vitro with the antiestrogen toremifene and recombinant human interferon-alpha 2.

Authors:  S P Robinson; D Goldstein; P L Witt; E C Borden; V C Jordan
Journal:  Breast Cancer Res Treat       Date:  1990-02       Impact factor: 4.872
  2 in total

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