Literature DB >> 3666151

A ferriprotoporphyrin IX-chloroquine complex promotes membrane phospholipid peroxidation. A possible mechanism for antimalarial action.

Y Sugioka1, M Suzuki, K Sugioka, M Nakano.   

Abstract

The effect of a ferriprotoporphyrin IX-chloroquine complex on phospholipid membranes was investigated on the basis of iron-induced lipid peroxidation using microsomal phospholipid liposomes. The ferriprotoporphyrin IX-chloroquine complex remarkably promoted peroxidative cleavage of unsaturated phospholipids in liposomes, compared with ferriprotoporphyrin IX alone. Neither the combination of protoporphyrin IX with chloroquine nor the combination of Fe3+-ADP with chloroquine promoted lipid peroxidation. DL-alpha-Tocopherol completely inhibited lipid peroxidation induced by the ferriprotoporphyrin IX-chloroquine complex.

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Year:  1987        PMID： 3666151     DOI： 10.1016/0014-5793(87)80299-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

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2.  A correlation study of quinoline derivatives and their pharmaceutical behavior by ab initio calculated NQR parameters.

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Journal:  J Comput Aided Mol Des       Date:  2004-03       Impact factor: 3.686

3.  Quantitative modeling of selective lysosomal targeting for drug design.

Authors:  Stefan Trapp; Gus R Rosania; Richard W Horobin; Johannes Kornhuber
Journal:  Eur Biophys J       Date:  2008-05-27       Impact factor: 1.733

4.  Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials.

Authors:  P Loria; S Miller; M Foley; L Tilley
Journal:  Biochem J       Date:  1999-04-15       Impact factor: 3.857

Review 5.  Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.

Authors:  Violetta N Pivtoraiko; Sara L Stone; Kevin A Roth; John J Shacka
Journal:  Antioxid Redox Signal       Date:  2009-03       Impact factor: 8.401

6.  A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes.

Authors:  Roxanne Openshaw; Keletso Maepa; Stefan J Benjamin; Lauren Wainwright; Jill M Combrinck; Roger Hunter; Timothy J Egan
Journal:  ACS Infect Dis       Date:  2021-01-12       Impact factor: 5.084

7.  Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum.

Authors:  Shivendra G Tewari; Sean T Prigge; Jaques Reifman; Anders Wallqvist
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2017-03-22       Impact factor: 4.077

Review 8.  Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story.

Authors:  Amin Gasmi; Massimiliano Peana; Sadaf Noor; Roman Lysiuk; Alain Menzel; Asma Gasmi Benahmed; Geir Bjørklund
Journal:  Appl Microbiol Biotechnol       Date:  2021-01-30       Impact factor: 4.813

9.  Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance.

Authors:  Sumit Bhattacharyya; Kemal Solakyildirim; Zhenqing Zhang; Robert J Linhardt; Joanne K Tobacman
Journal:  Malar J       Date:  2009-12-17       Impact factor: 2.979

Review 10.  Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection.

Authors:  Jinjin Zhu; Yang Wang; Yuanyuan Cao; Jilong Shen; Li Yu
Journal:  Front Microbiol       Date:  2021-06-17       Impact factor: 5.640
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