| Literature DB >> 3666145 |
A Brossi1, W Gessner, C D Hufford, J K Baker, F Homo, P Millet, I Landau.
Abstract
Photooxidation of primaquine (1) and 5-hydroxyprimaquine (5) afforded a blue dye for which o-quinone structure 4 was elaborated. Similar oxidation of N-ethoxyacetylprimaquine (10) afforded o-quinone 11. Tissue schizontocidal activity of 4 and 11, and bisquinolylmethine 3 prepared earlier, showed that none of them had noteworthy antimalarial activity, but all three produced methemoglobin.Entities:
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Year: 1987 PMID： 3666145 DOI： 10.1016/0014-5793(87)80513-6
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124