Literature DB >> 3666132

Down-regulation of phorbol diester binding to NG115-401L neuronal cells is dependent on structure, concentration and time.

R R Mattingly1, M L Dreher, M R Hanley.   

Abstract

The down-regulation of [3H]PDBu binding to a neural cell line, NG115-401L, has been examined in response to two biologically active phorbol diesters, PDBu and PMA. Chronic treatment with PDBu or PMA causes a concentration- and time-dependent loss of specific [3H]PDBu binding. The action of PMA is biphasic with respect to both concentration and time dependence.

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Year:  1987        PMID: 3666132     DOI: 10.1016/0014-5793(87)80500-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  2 in total

1.  Protein kinase C regulates the tonic but not the phasic component of contraction in guinea-pig ileum.

Authors:  T Sasaguri; S P Watson
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

2.  Contractile and relaxant effects of phorbol ester in the intestinal smooth muscle of guinea-pig taenia caeci.

Authors:  M Mitsui; H Karaki
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

  2 in total

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