Literature DB >> 3666005

Possible involvement of protein kinase C (PKC) in the regulation of electrically evoked serotonin (5-HT) release from rabbit hippocampal slices.

T J Feuerstein1, C Allgaier, G Hertting.   

Abstract

Protein kinase C (PKC)-activating phorbol esters enhanced the electrically evoked 5-HT release from rabbit hippocampal slices preincubated with [3H]5-HT. The release was diminished by polymyxin B, an inhibitor of PKC. These results are compatible with a stimulatory effect of PKC on the 5-HT release induced by action potentials. The mutual effects of PKC affecting drugs on 5-HT release suggest a functional but not a competitive interaction. The attenuation or the enhancement of effects of 5-HT autoreceptor ligands at various 5-HT biophase concentrations found after PKC-affecting drugs are in line with the view that autoreceptor-mediated events are not directly influenced by the enzyme PKC.

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Year:  1987        PMID： 3666005     DOI： 10.1016/0014-2999(87)90583-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

Review 1.  The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.

Authors:  P J Robinson
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

2.  The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex.

Authors:  L Iannazzo; P Kotsonis; H Majewski
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

3.  Involvement of adenylate cyclase and protein kinase C in the alpha 2-adrenoceptor-mediated inhibition of noradrenaline and 5-hydroxytryptamine release in rat hypothalamic slices.

Authors:  R Ramdine; A M Galzin; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

4.  Protein kinase C and presynaptic modulation of acetylcholine release in rabbit hippocampus.

Authors:  C Allgaier; B Daschmann; H Y Huang; G Hertting
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

5.  A role for protein kinase C in the electrically evoked release of [3H] gamma-aminobutyric acid in rabbit caudate nucleus.

Authors:  P Bartmann; R Jackisch; G Hertting; C Allgaier
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-03       Impact factor: 3.000

6.  Influence of phorbol esters on stimulation-induced noradrenaline release and contractile force of isolated guinea-pig atria.

Authors:  H Brasch
Journal:  Basic Res Cardiol       Date:  1991 May-Jun       Impact factor: 17.165
  6 in total

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