Literature DB >> 3665631

Ciprofloxacin concentrations in human aqueous humor following intravenous administration.

W Behrens-Baumann1, J Martell.   

Abstract

16 patients received an intravenous infusion of 200 mg ciprofloxacin 1, 2, 3 and 6 h, respectively, before cataract extraction. This dosage produced mean aqueous humor levels of 0.165 +/- 0.09 and 0.126 +/- 0.028 microgram/ml after 1 and 3 h, respectively. The mean serum levels were 1.760 +/- 0.873 and 0.854 +/- 0.283 microgram/ml after 1 and 3 h, respectively. These levels are above the minimum inhibitory concentration of ciprofloxacin for sensitive organisms.

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Year:  1987        PMID: 3665631     DOI: 10.1159/000238517

Source DB:  PubMed          Journal:  Chemotherapy        ISSN: 0009-3157            Impact factor:   2.544


  6 in total

1.  Pharmacokinetics of ciprofloxacin in the human eye: a clinical study and population pharmacokinetic analysis.

Authors:  N Morlet; G G Graham; B Gatus; A J McLachlan; C Salonikas; D Naidoo; I Goldberg; C M Lam
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

2.  Efficacy and ocular penetration of sparfloxacin in experimental streptococcal endophthalmitis.

Authors:  I Cochereau-Massin; J Bauchet; S Marrakchi-Benjaafar; A Saleh-Mghir; F Faurisson; J M Vallois; E Vallee; J J Pocidalo
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

Review 3.  Use of quinolones for treatment of ear and eye infections.

Authors:  M Barza
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-04       Impact factor: 3.267

Review 4.  Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  D M Campoli-Richards; J P Monk; A Price; P Benfield; P A Todd; A Ward
Journal:  Drugs       Date:  1988-04       Impact factor: 9.546

5.  Ocular pharmacokinetics of tobramycin. A comparative radioimmunoassay and microbiological assay.

Authors:  S Desai
Journal:  Int Ophthalmol       Date:  1993-08       Impact factor: 2.031

6.  Comparative pharmacokinetics of ciprofloxacin, ofloxacin and pefloxacin in human aqueous humour.

Authors:  H Giamarellou; D Kanellas; E Kavouklis; G Petrikkos; L Gabriel
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1993-04       Impact factor: 3.267

  6 in total

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