| Literature DB >> 3665194 |
R B Minson1, R J McRitchie, J P Chalmers.
Abstract
1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1-30 micrograms/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 micrograms/kg. Beyond 10 micrograms/kg there are only slight effects on heart rate or peak LV dP/dt.Entities:
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Year: 1987 PMID： 3665194 DOI： 10.1111/j.1440-1681.1987.tb00387.x
Source DB: PubMed Journal: Clin Exp Pharmacol Physiol ISSN： 0305-1870 Impact factor: 2.557