Literature DB >> 3665185

Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus.

N Neu1, S W Craig, N R Rose, F Alvarez, K W Beisel.   

Abstract

After infection with Coxsackievirus B3 (CB3), H-2 congenic strains of mice on an A-background develop an immunologically mediated myocarditis associated with autoantibodies directed mainly against cardiac myosin. We tested these autoantibodies for cross-reactivity with the virus. Using immunoblotting and virus neutralizing assays with affinity purified antibodies and absorbed sera, we found that the autoantibodies to heart myosin did not cross react with CB3. In addition, myosin autoantibodies induced by immunization with cardiac myosin did not react with the virus. Western immunoblotting revealed that the anti-CB3 antibodies in the infected mice are directed against the capsid protein VP 2. We conclude that CB3 antigens do not stimulate an immune response that cross-reacts with cardiac myosin.

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Year:  1987        PMID： 3665185      PMCID： PMC1542369     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  32 in total

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Journal:  Virology       Date:  1973-07       Impact factor: 3.616

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Journal:  Clin Exp Immunol       Date:  1970-08       Impact factor: 4.330

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Journal:  Clin Exp Immunol       Date:  1979-11       Impact factor: 4.330

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Authors:  R L Crowell; L Philipson
Journal:  J Virol       Date:  1971-10       Impact factor: 5.103

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Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307

10.  IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS.

Authors:  M H KAPLAN; K H SVEC
Journal:  J Exp Med       Date:  1964-04-01       Impact factor: 14.307
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  26 in total

Review 1.  Coxsackievirus infection as a trigger of cardiac autoimmunity.

Authors:  L J Wolfgram; N R Rose
Journal:  Immunol Res       Date:  1989       Impact factor: 2.829

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Authors:  Robert S Fujinami; Matthias G von Herrath; Urs Christen; J Lindsay Whitton
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

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Authors:  M Herzum; B Maisch
Journal:  Springer Semin Immunopathol       Date:  1989

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Journal:  Clin Exp Immunol       Date:  1991-12       Impact factor: 4.330

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Authors:  K W Beisel
Journal:  Springer Semin Immunopathol       Date:  1989

6.  Congenital heart disease linked to maternal autoimmunity against cardiac myosin.

Authors:  Charles R Cole; Katherine E Yutzey; Anoop K Brar; Lisa S Goessling; Sarah J Van Vickle-Chavez; Madeleine W Cunningham; Pirooz Eghtesady
Journal:  J Immunol       Date:  2014-03-26       Impact factor: 5.422

Review 7.  The clinical and diagnostic significance of anti-myosin autoantibodies in cardiac disease.

Authors:  Udi Nussinovitch; Yehuda Shoenfeld
Journal:  Clin Rev Allergy Immunol       Date:  2013-02       Impact factor: 8.667

Review 8.  Unresolved issues in theories of autoimmune disease using myocarditis as a framework.

Authors:  Robert Root-Bernstein; DeLisa Fairweather
Journal:  J Theor Biol       Date:  2014-12-04       Impact factor: 2.691

9.  Similar prevalence of enteroviral genome within the myocardium from patients with idiopathic dilated cardiomyopathy and controls by the polymerase chain reaction.

Authors:  P J Keeling; S Jeffery; A L Caforio; R Taylor; G F Bottazzo; M J Davies; W J McKenna
Journal:  Br Heart J       Date:  1992-12

10.  Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.

Authors:  C A von Mühlen; E K Chan; C L Peebles; H Imai; K Kiyosawa; E M Tan
Journal:  Clin Exp Immunol       Date:  1995-04       Impact factor: 4.330
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