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Literature DB >> 3664271

Hyperalgesia to heat after intradermal injection of capsaicin.

D A Simone¹, J Y Ngeow, G J Putterman, R H LaMotte.

Abstract

Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 micrograms, given in a constant volume of 10 microliter. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.

Entities: Chemical Disease Species

Mesh：

Substances：
Capsaicin

Year: 1987 PMID： 3664271 DOI： 10.1016/0006-8993(87)90982-6

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

28 in total

1. Transient cold pain has no effect on cutaneous vasodilatation induced by capsaicin: a randomized-control-crossover study in healthy subjects.

Authors: Dorit Pud; Ole Kaeseler Andersen; Lars Arendt-Nielsen; David Yarnitsky
Journal: Pflugers Arch Date: 2005-11-22 Impact factor: 3.657

Review 2. The endocannabinoid system and pain.

Authors: Josée Guindon; Andrea G Hohmann
Journal: CNS Neurol Disord Drug Targets Date: 2009-12 Impact factor: 4.388

3. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

Authors: R H LaMotte; L E Lundberg; H E Torebjörk
Journal: J Physiol Date: 1992-03 Impact factor: 5.182

Review 4. Unravelling the mystery of capsaicin: a tool to understand and treat pain.

Authors: Jessica O'Neill; Christina Brock; Anne Estrup Olesen; Trine Andresen; Matias Nilsson; Anthony H Dickenson
Journal: Pharmacol Rev Date: 2012-10 Impact factor: 25.468

5. Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.

Authors: Thaddeus S Brink; Cholawat Pacharinsak; Sergey G Khasabov; Alvin J Beitz; Donald A Simone
Journal: J Neurophysiol Date: 2011-10-26 Impact factor: 2.714

6. Thermosensitive transient receptor potential (TRP) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal models.

Authors: A H Klein; Minh Trannyguen; Christopher L Joe; Carstens M Iodi; E Carstens
Journal: Chemosens Percept Date: 2015-08 Impact factor: 1.833

Hyperalgesia to heat after intradermal injection of capsaicin.

1. Transient cold pain has no effect on cutaneous vasodilatation induced by capsaicin: a randomized-control-crossover study in healthy subjects.

Review 2. The endocannabinoid system and pain.

3. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

Review 4. Unravelling the mystery of capsaicin: a tool to understand and treat pain.

5. Differential modulation of neurons in the rostral ventromedial medulla by neurokinin-1 receptors.

6. Thermosensitive transient receptor potential (TRP) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal models.

Review 7. Moving towards supraspinal TRPV1 receptors for chronic pain relief.

8. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel.

9. Differential effect of capsaicin treatment on pain-related behaviors after plantar incision.

10. Expression and function of proton-sensing G-protein-coupled receptors in inflammatory pain.